My name is Hunter Williams and I am a creator, entrepreneur, and biohacker. On the my podcast, we talk about things that are on the fringe of health, fitness, and biohacking. From peptides, hormones, and fat loss, to biohacking and spirituality, we cover everything about health and fitness that the mainstream doesn't want you to know!
My name is Hunter Williams and I am a creator, entrepreneur, and biohacker. On the my podcast, we talk about things that are on the fringe of health, fitness, and biohacking. From peptides, hormones, and fat loss, to biohacking and spirituality, we cover everything about health and fitness that the mainstream doesn't want you to know!
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In today’s video I unpack amlexanox—an old anti-inflammatory/allergy drug with surprising metabolic effects. I share my first encounter with it in the research-chem world, what I noticed subjectively, and then dive into mechanisms (IKKε/TBK1 inhibition, catecholamine resensitization, beige fat), rodent data, the Phase 2 human trial (150 mg/day), safety, dosing, who seems to respond best, and how I’m stacking it inside Bio Ignite. If your goal is fat loss with stubborn adipose inflammation, this is worth understanding.
0:00 - Welcome + what today’s video covers
0:28 - How I first found “AM Lox” browsing catalogs
1:06 - Cycling off SLU-PP-332 and first personal trial
1:40 - Noticing dryness/ab definition; early under-dosing
2:12 - 2025 “sugar diet” + hunting for FGF21 boosters
2:40 - Finding data that amlexanox increases FGF21
3:02 - Literature dosage (100–150 mg) vs my early dose
3:38 - Why I think it’s a useful fat-loss rotation tool
4:24 - Channel/hosting update + where to find my videos
5:08 - Slides start: what amlexanox is/was used for
6:00 - Core mechanism: IKKε/TBK1 → PDE3B → cAMP resistance
7:16 - IL-6→STAT3 hepatic signaling + beigeing via FGF21
8:30 - Big-picture benefits: inflammation, insulin sensitivity, glycemia
10:32 - Human data: Phase 2 trial (150 mg/day x 12 weeks)
11:10 - Modest/variable weight change; who improved most
12:37 - Practical takeaways: glycemia, liver fat, insulin sensitivity
14:12 - Dosing in practice (50 mg caps, TID = 150 mg/day)
15:12 - Responder phenotype: high adipose inflammation
16:00 - Who benefits most + variability at similar body fat
17:56 - Study roll-up and mechanism recap
18:52 - Final thoughts, use-cases, and product note (Bio Ignite)
19:54 - Thank you + where to grab the peptide cheat sheet
What You'll Learn
Why amlexanox can “release the brakes” on fat-burning by inhibiting IKKε/TBK1 and restoring cAMP/catecholamine responsiveness.
How it raises IL-6 transiently in adipose, activates STAT3 in the liver, suppresses gluconeogenesis, and increases FGF21 to promote beige fat programs.
The mouse vs. human gap: robust fat loss in mice; in humans, clearer improvements in A1c, fructosamine, liver fat, insulin sensitivity—especially when adipose inflammation is high.
Dosing used in the Phase 2 trial: 50 mg TID (total 150 mg/day) for 12 weeks.
Safety snapshot: no serious AEs attributed to amlexanox in metabolic trials; most common was a transient rash.
Timestamps (exact to the transcript)What you’ll learn