Abstract: Traditional motivation theories position desire as the precursor to action, but contemporary neuroscience reveals a more nuanced mechanism: effort itself generates the neurochemical signals that sustain motivated behavior. Dopaminergic pathways respond not primarily to reward consumption but to goal pursuit, effort expenditure, and progress detection. This reversal has profound implications for how organizations design work systems, structure goals, and support sustained performance. Rather than waiting for intrinsic motivation to emerge, evidence suggests that behavioral activation—initiating effort even in low-motivation states—triggers dopamine release that reinforces continued action. This article synthesizes research from neuroscience, organizational psychology, and behavioral economics to examine how effort-motivation loops function, their impact on individual and organizational outcomes, and evidence-based interventions that leverage these mechanisms. Organizations that structure work to emphasize visible progress, effort recognition, and iterative achievement create neurobiological conditions for self-sustaining motivation, reducing dependence on external incentives while improving wellbeing and performance outcomes.