Summary In this episode of the Future of Dermatology podcast, guest speaker Dr. Donna Culton, delves into the intricate science of skin diseases, focusing on the pathophysiology of conditions like pemphigoid. The discussion covers the roles of B cells, autoantibodies, and various cellular players in inflammation, as well as the mediators that contribute to symptoms like itch. The episode emphasizes the complexity of these diseases and the potential for new therapeutic targets, while also highlighting the challenges in conducting clinical trials for affected populations. Takeaways - Dr. Culton emphasizes the importance of understanding B cells in skin diseases.- Pemphigus and pemphigoid have distinct clinical presentations and treatments.- Autoantibodies play a crucial role in the pathophysiology of pemphigoid.- Mast cells and eosinophils are key players in the inflammatory response.- Cytokines like IL-4 and IL-5 are critical for B cell activation and eosinophil recruitment.- The itch associated with pemphigoid is complex and not solely due to histamine.- Clinical trials for skin diseases face unique challenges due to patient comorbidities.- Understanding the mediators of degradation can inform treatment strategies.- The complexity of skin diseases allows for multiple therapeutic targets.- This podcast serves as an educational resource for understanding dermatological science. Chapters 00:00 - Introduction to Dermatology and B Cells02:51 - Understanding Pemphigus and Pemphigoid05:25 - The Role of Autoantibodies in Skin Diseases08:20 - Key Cellular Players in Inflammation10:53 - Mediators of Inflammation and Itch13:57 - Pathophysiology and Future Therapies