In this podcast we discuss Serrated Polyps with Professor Neil Shepherd. There is much more to these lesions than Size and Number!  Did you know that there may be two distinct syndromes and it's the Site of the lesions which distinguishes the two?  That is just the start.  It gets weirder!  We cover a huge amount of ground and headings include (in chronological order): Serrated polyps - one or two distinct syndromes? Can you tell histologically? How does the Serrated Polyposis Syndrome fit ? What matters the most when deciding on the significance of a serrated polyp? Dysplasia inside a serrated polyp? - Well it's complicated !  The heterogeneity of serrated lesions is also problematic Could AI help the Pathologist in the future? How can we identify patients with serrated polyposis syndrome ? Can we explain finding both serrated and adenomatous polyps in serrate polyposis syndrome? Why should I refer patient with serrated polyposis syndrome to geneticists? Can we tell which cancer has developed from a serrated precursor? What is the link between serrated polyps and colitis? The weird issue of stromal changes below serrated polyps 'Mixed polyp' or 'collision polyp'? How can we as endoscopist help the pathologist? Do you believe in DISCARD? What remains the remit of the pathologist to diagnose?