5 January 2023 - “Nobody is doubling the number of cell types,” says Steve Quake, “but what we have now is the full molecular portrait of those cell types”. Quake, who led a decade-long effort to create full organism molecular cell atlases, served for six years as co-President of the Chan Zuckerberg Biohub. He succeeded neuroscientist Cori Bargmann as Head of Science for the Chan Zuckerberg Initiative. Quake came to biology after undergraduate and graduate work in physics and mathematics, and his research group at Stanford has maintained a strong technological and quantitative focus. On this episode of the EMBO podcast, we discussed what a cell type is, Open Science and preprints (Quake and student Michael Swift are currently experimenting with Review Commons – “the jury’s still out,” he says), the role of funders, how to start a company, and much more.