What if a simple yeast, scraped from the peel of tropical fruit during a cholera epidemic, could change the way we protect our microbiome? 

In the 1920s, French microbiologist Henri Boulard stumbled upon a probiotic unlike any other. Saccharomyces boulardii isn’t a bacteria, but a hardy yeast that survives heat, stomach acid, and bile. Today, it’s one of the best-studied tools for preventing antibiotic-associated diarrhea, treating traveler’s diarrhea, and protecting gut health when illness strikes. 

In this episode of Tribulations, Dr. Ravi Kumar takes you on a journey that weaves history, science, and practical medicine. You’ll discover: 

• The remarkable story of how Boulard’s curiosity led him from alcohol fermentation to a lifesaving probiotic during a cholera outbreak.
• Why Saccharomyces boulardii acts as a “shepherd” in the gut, preserving balance while pushing back against harmful bacteria.
• Clinical trial evidence showing its effectiveness against antibiotic-associated diarrhea, traveler’s diarrhea, and recurrent C. difficile infection.
• Practical dosing strategies for adults and children—when to use it, how long to continue, and important safety caveats.
• Why a $15 supplement sometimes outperforms prescriptions in protecting your microbiome.

It’s a story of serendipity, science, and a forgotten yeast that still holds lessons for modern medicine.
 
For references: drkumardiscovery.com/podcast

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