In this episode of Demystifying Cosmetics, host Jennifer Cookson sits down with Mercedes Amans, Head of Product at ClearSTEM, to explore the evolving science and strategy behind formulating products that are both acne-safe and anti-aging. Mercedes shares how ClearSTEM challenges outdated definitions of comedogenicity, leverages data from real consumers, and uses biotech innovation to fill a major gap in skincare. From ingredient myth-busting to the limitations of current testing methods, this episode is a masterclass for anyone working at the intersection of skin sensitivity, science, and beauty.Takeaways:• Acne + Aging Can Coexist: ClearSTEM is disrupting the belief that anti-aging products must sacrifice acne safety—and vice versa.• Not All “Clean” is Acne-Safe: Many natural or clean-labeled ingredients (like coconut oil or algae extracts) are actually highly comedogenic.• Testing Matters: ClearSTEM prioritizes follicular biopsy testing and sensitive-skin clinical trials to ensure safety and efficacy for acne-prone consumers.• Surfacing Safe Surfactants: With improved technologies like glycolipids and phospholipids, it’s now possible to build effective non-irritating formulas without traditional PEGs or polysorbates.• Cleansing is Key: A good cleanser twice a day is foundational—especially in today’s pollution-heavy, sunscreen-drenched environment.• Biotech = The Future: Biotech ingredients offer clean, sustainable, high-performance options—but consumer education still lags behind.• Label Confusion: Terms like “non-comedogenic” or “natural” are often meaningless without standardized testing and transparency.