In this episode of the College of Glycation series, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—reveals the overlooked but critical connection between glycation and sleep. Far from being a passive state, sleep is when the brain and body perform vital repair work, yet advanced glycation end products (AGEs) can sabotage this process. From disrupting melatonin production and circadian rhythms to worsening conditions like sleep apnea, insomnia, and restless leg syndrome, glycation quietly undermines our most restorative rhythms.

Drawing on cutting-edge research, Dr. Reynolds explains how poor sleep, insulin resistance, and glycation form a destructive cycle—and, most importantly, how diet, exercise, stress management, and sleep hygiene can help break it. If you’ve ever struggled with sleep quality or want to protect long-term health, this episode offers both the science and the practical steps you need.