In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—explores the surprising biochemical connection between glycation and Polymyalgia Rheumatica (PMR), a painful inflammatory disorder that limits movement and quality of life. He explains how advanced glycation end-products (AGEs) can stiffen collagen, alter fascia, and transform the interstitial fluid that should keep muscles and joints moving freely—creating the perfect environment for pain and rigidity.

Drawing on recent studies, Dr. Reynolds reveals how diet, inflammation, and oxidative stress intertwine in PMR, and why reducing sugar intake may help break the cycle. He also discusses ketogenic and low-carb eating as potential tools to lower AGE burden and ease stiffness, offering practical steps for protecting connective tissue health at any age.