In this episode of the College of Glycation series, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—reveals how sugar’s toxic fingerprints reshape the liver and fuel a silent epidemic: non-alcoholic fatty liver disease (NAFLD) and its aggressive cousin, NASH. Glycation and its byproducts, known as AGEs, act like molecular graffiti—damaging proteins, inflaming tissues, and driving fibrosis that can progress to cirrhosis and liver failure.

Drawing on decades of research, Dr. Reynolds unpacks the biochemical chain reaction behind liver disease, from insulin resistance and de novo lipogenesis to RAGE signaling and stellate cell activation. Most importantly, he highlights evidence-based strategies—low-carb diets, intermittent fasting, exercise, and stress reduction—that can halt or even reverse early damage. Whether you’re concerned about metabolic health or simply want to protect your liver, this lecture offers practical tools and empowering science to take control.