In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—reveals how glycation, the sugar-driven process that creates AGEs (advanced glycation end products), undermines human fertility. From sperm DNA damage and declining egg quality to impaired endometrial receptivity and placental dysfunction, glycation silently sabotages reproduction in both men and women. Linked to PCOS, endometriosis, male infertility, and gestational diabetes, this biochemical “rust” is emerging as a hidden driver of today’s fertility crisis.

Drawing on peer-reviewed studies and clinical insights, Dr. Reynolds explains how AGEs alter reproductive biology—and, most importantly, what can be done about it. Listeners will learn actionable strategies to reduce AGE burden through diet, lifestyle, and promising new therapies. Whether you’re navigating fertility challenges, pregnancy complications, or simply seeking to better understand reproductive health, this episode offers a clear, science-backed roadmap for protecting the next generation.