Today we talk with Danny Almirall from the University of Michigan's d3C center. We talk about how learning about prime numbers set Danny up for a lifetime of teaching people about math, statistics, and methods, the difference between efficacy, effectiveness, and implementation studies, what is a SMART trial, and how do SMART trials inform adaptive interventions, what are MAISYs, and we learn a little bit about Salsa the dance and just a tiny bit about Salsa the food. And We mention the following papers: Kevin’s paper on implementation science and quantitative methods King, K. M., Pullmann, M. D., Lyon, A. R., Dorsey, S., & Lewis, C. C. (2019). Using implementation science to close the gap between the optimal and typical practice of quantitative methods in clinical science. Journal of abnormal psychology, 128(6), 547. (http://depts.washington.edu/risemh/wordpress/wp-content/uploads/2019/08/King-et-al-2019-JAbnormal-1.pdf) SMART designs: Almirall, D., Nahum-Shani, I., Sherwood, N. E., & Murphy, S. A. (2014). Introduction to SMART designs for the development of adaptive interventions: with application to weight loss research. Translational behavioral medicine, 4(3), 260–274. https://doi.org/10.1007/s13142-014-0265-0  Beidas premortem paper: Beidas, R. S., Dorsey, S., Lewis, C. C., Lyon, A. R., Powell, B. J., Purtle, J., ... & Lane-Fall, M. B. (2022). Promises and pitfalls in implementation science from the perspective of US-based researchers: learning from a pre-mortem. Implementation Science, 17(1), 55. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375077/) Danny recommends we check out: Brian Weiner (https://globalhealth.washington.edu/faculty/bryan-weiner) Susan Murphy, PhD. (http://people.seas.harvard.edu/~samurphy/ ) Danny’s Website: https://d3c.isr.umich.edu/, and https://twitter.com/d3_center