Dr. Génessier (Pierre Brasseur) is riddled with guilt after an accident that he caused disfigures the face of his daughter, the once beautiful Christiane (Edith Scob), who outsiders believe is dead. Dr. Génessier, along with accomplice and laboratory assistant Louise (Alida Valli), kidnaps young women and brings them to the Génessier mansion. After rendering his victims unconscious, Dr. Génessier removes their faces and attempts to graft them on to Christiane's.
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