Biochemical and forensic experts from the Science and Technology Directorate (S&T) and Pacific Northwest National Laboratory (PNNL) visited one of the nation’s busiest (and loudest) ports of entry in Mariposa, Arizona. With this as our backdrop, listen as the group discusses research and development of a novel fentanyl detector designed to improve screening for illicit drugs. S&T’s Dan Conway leads a conversation with Dr. Andrea Wiggins of S&T’s Chemical Biological Detection and Defense Program; Travis Brown, S&T Program Manager for Forensics and Criminal Investigation; Dr. Laura Parker, S&T Senior Advisor on Sensors and Detection; and PNNL Senior Research Chemist Dr. Robert Ewing about how this new technology was demonstrated and could soon be used and overall challenges with combating the flow of fentanyl.