Most communities aiming to replicate Silicon Valley overlook the essential foundation for entrepreneurial success: healthy ecosystems. In a conversation with Alfredo Mathew, founder of ESO Ventures, we explored the gaps in ecosystem building and solutions to empower entrepreneurs. Alfredo emphasizes that ecosystems must prioritize founders with skin in the game, supported by public, private, and philanthropic partnerships. His "four P model" highlights private capital for scalability, public funds for momentum, and philanthropy to close gaps. Successful ecosystems start with founder-first support, focusing on experienced professionals with domain expertise. Alfredo challenges the "youth bias," arguing 40-60-year-olds make the best entrepreneurs due to life experience and resilience. Key takeaways include: building delegable systems, leveraging AI for niche solutions, and showcasing local success stories to attract talent and resources. Ecosystem building requires collaboration, education, and a shift from job creation to asset ownership for sustainable growth.