With his solemn, near pious, Sonnet 146, William Shakespeare for the first and only time speaks directly to his soul and entreats it to look after itself; to stop expending its energy on the pursuit of outward, physical adornments which are all doomed to swift decay – effectively starving and weakening itself whilst feeding and strengthening the gluttonous body that is only meant to house it and that will soon succumb to death – and to instead let go of material riches and with the 'return' from 'selling' them, 'purchase' something infinitely more valuable: eternal life in concord with, and on the terms ordained by, God.

The poem makes no mention, nor does it allude to or reference indirectly, any lover, mistress, or wife, nor love itself, or sex. This, too, makes it unique in the collection. As does its close alignment with a Christian notion of redemption through spiritual nurture at the expense of, and in preference to, physical or material gratification.