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Recent achievements of cell reprogramming pave the way for the successful implementation of full rejuvenation of cells from old mammals. This paradigm shift reveals that a small number of master genes could take a senile somatic cell from a state of apparent terminal dysfunction to a condition of youthful vitality. In vivo human rejuvenation is being studied that may be based on the revitalizing power of a few master genes. Once attained, clinical rejuvenation is expected to markedly extend human maximum healthy lifespans until immortality is achieved likely via the brain-cloud interface.

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