Disclaimer: This podcast is not sponsored by or associated with any of the products mentioned in today's episode.
In this episode of Skinfluenced: The Skin Podcast, we break down the FDA’s recent approval of Libtayo® (Cemiplimab-rwlc) as the first and only adjuvant immunotherapy for patients with high-risk cutaneous squamous cell carcinoma (cSCC) following surgery and radiation.
Join us as we discuss:🧬 The pivotal trial showing improved disease-free survival in high-risk cSCC💉 The evolving role of PD-1 blockade in post-surgical skin cancer management🧠 How this approval changes the treatment landscape for patients at risk of recurrence
This landmark decision represents a major step forward in skin cancer care—bringing immunotherapy into the adjuvant setting and offering new hope for patients facing aggressive or recurrent cSCC.
Link to Source(s):
American Association for Cancer Research. Immunotherapy Approved for Preventing Recurrence of Certain Skin Cancers. Accessed October 22, 2025. https://tinyurl.com/ywpynwfn
American Journal of Managed Care. FDA Approves Cemiplimab as First & Only Adjuvant Immunotherapy for High-Risk cSCC. Accessed October 22, 2025. https://tinyurl.com/5b4s6jb7
Dermatology Advisor. FDA Approves Libtayo for Adjuvant Treatment of High-Risk cSCC. Accessed October 22, 2025. https://tinyurl.com/58h5cckn
Derm Digest. FDA Approves Cemiplimab to Treat cSCC With High Risk of Recurrence After Surgery and Radiation. Accessed October 22, 2025. https://tinyurl.com/2s9jjc53
Journal of Clinical Oncology. Adjuvant Libtayo (cemiplimab) Significantly Improves Disease-Free Survival in Patients With High-Risk Cutaneous Squamous Cell Carcinoma. Published 2025; 43(16_suppl):6000. Accessed October 22, 2025. https://tinyurl.com/27ekuzch
New England Journal of Medicine. Adjuvant Cemiplimab for Cutaneous Squamous-Cell Carcinoma. Published 2025. Accessed October 22, 2025. https://tinyurl.com/4rynuvky
OncLive. Dr. Patel on the FDA Approval of Adjuvant Cemiplimab for High-Risk Cutaneous Squamous Cell Carcinoma. Accessed October 22, 2025. https://tinyurl.com/4kvzbv8z
Oncology Nursing Society. FDA Approves Cemiplimab-rwlc for Adjuvant Treatment of High-Risk Cutaneous Squamous Cell Carcinoma. Published October 2025. Accessed October 22, 2025. https://tinyurl.com/4ne9rsv3
Regeneron Pharmaceuticals. Adjuvant Libtayo (cemiplimab) Significantly Improves Disease-Free Survival in Phase 3 Trial. Accessed October 22, 2025. https://tinyurl.com/3a9m5u6c
Regeneron Pharmaceuticals. FDA Approves Libtayo (cemiplimab-rwlc) in the U.S. as the First and Only Adjuvant Immunotherapy for High-Risk cSCC. Accessed October 22, 2025. https://tinyurl.com/2hfs59k2
Regeneron Pharmaceuticals. Libtayo (cemiplimab) Phase 3 Data: Adjuvant Treatment Post-Surgery and Radiation. Accessed October 22, 2025. https://tinyurl.com/yx5xkzcr
Regeneron Pharmaceuticals. Libtayo Full Prescribing Information. Accessed October 22, 2025. https://tinyurl.com/86w7ydjn
Regeneron Pharmaceuticals. Libtayo Medication Guide. Accessed October 22, 2025. https://tinyurl.com/432jx77u
ScienceDirect. Induction of Natural Cytotoxicity by Interferon: Studies on the Mechanism of Action. Trends in Biochemical Sciences. Published 1985. Accessed October 22, 2025. https://tinyurl.com/589swev2
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