Disclaimer: This podcast is not sponsored by or associated with any of the products mentioned in today's episode.
In this episode of Skinfluenced: The Skin Podcast, we break down the recent FDA approval of Anzupgo (delgocitinib) cream 2%, the first and only topical prescription treatment approved in the U.S. specifically for moderate to severe chronic hand eczema (CHE) in adults. We cover what CHE is, how it impacts patients, why this approval is so significant, and the science behind this non-steroidal topical JAK inhibitor.
We also explore insights from the DELTA 1 and DELTA 2 phase 3 trials, patient-reported outcomes, and what this means for clinical practice. If you treat eczema or know someone suffering from persistent hand dermatitis, this is a must-listen!
Links to Source(s):
Dermatology Times (2025): FDA Approves Delgocitinib for Chronic Hand Eczema: https://www.dermatologytimes.com/view/fda-approves-delgocitinib-for-chronic-hand-eczema
Business Wire (July 2025): ANZUPGO (Delgocitinib) Cream is Now the First and Only FDA-Approved Treatment for Moderate to Severe Chronic Hand Eczema in Adults: https://www.businesswire.com/news/home/20250723115252/en
LEO Pharma Official Announcement: FDA Approval for ANZUPGO (Delgocitinib) Cream 2%: https://www.leo-pharma.com/media-center/news/2025-fda-approval
Journal of Dermatology and Therapy (2025): Health-Related Quality of Life in Chronic Hand Eczema in a Phase 2b Trial of Delgocitinib Cream: https://doi.org/10.1007/s13555-025-01384-4
University of Groningen (2025): Efficacy and Safety of Delgocitinib Cream in Adults with Moderate-to-Severe Chronic Hand Eczema: https://research.rug.nl/en/publications/efficacy-and-safety-of-delgocitinib-cream-in-adults-with-moderate
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