E16   |  16 min   |   Latest   |  Publication Source    Podcast based on: Boydell E, Borgeaud M, Tsantoulis P. Dormant Tumor Cells: Current Opportunities and Challenges in Clinical Practice. Onco. 2025; 5(1):3. https://doi.org/10.3390/onco5010003Type: Review  |  Publication date: Jan 10, 2025 Summary: This research review examines dormant tumour cells, cells that remain inactive after cancer treatment, potentially causing relapse. It explores the molecular mechanisms underlying dormancy, the role of the immune system and microenvironment, and the challenges in detecting these cells clinically. The review also discusses potential therapeutic strategies, including maintaining dormancy, eradicating dormant cells, and targeting the tumour's niche, highlighting the complexities and limitations of current approaches. Finally, it emphasises the need for clinically meaningful endpoints in future trials focusing on dormant tumour cells. Keywords: disseminated tumor cells; dormancy; minimal residual disease; breast cancer Disclaimer:This podcast provides a synthetically generated voice summary and discussion of scientific publications. The views expressed do not represent the views of the original authors, journals, or publishers. While efforts are made to ensure accuracy, this podcast uses AI-assisted summaries, so it may or may not introduce inaccuracies or omit important details. Listeners are strongly encouraged to consult the original publications or sources for full context and accuracy. This podcast is for educational and informational purposes only and does not constitute clinical advice, medical guidance, or recommendations. The creators of this podcast are not liable for any errors, omissions, or outcomes resulting from the use of the information provided.