E6   |   10 min   |   Latest   |  Publication Source    Podcast based on: Alerasool P, Zhou S, Miller E, Anker J, Tsao B, Kyprianou N, Tsao C-K. A Personalized Approach for Oligometastatic Prostate Cancer: Current Understanding and Future Directions. Cancers. 2025; 17(1):147. https://doi.org/10.3390/cancers17010147Type: Review  |  Publication date: Jan 5, 2025 Summary: This research review examines oligometastatic prostate cancer (OMPC), an intermediate stage between localised and widespread disease offering potential for cure. The article explores diagnostic challenges, focusing on PSMA PET scans, and reviews current treatment strategies, including metastasis-directed therapy (MDT) and combinations of systemic therapies with prostate cytoreduction. Ongoing clinical trials investigating MDT and various systemic therapies are highlighted, alongside the potential of artificial intelligence for personalised treatment. The authors emphasise the need for clearer OMPC definitions and the development of predictive biomarkers to optimise treatment selection and improve patient outcomes. Future directions focus on improving diagnostic accuracy, developing novel therapies, and leveraging artificial intelligence to refine treatment strategies. Keywords: prostate cancer; oligometastatic disease; oligometastasis; stereotactic body radiotherapy; focal therapy; androgen deprivation therapy; metastasis-directed therapy; castration-resistant prostate cancer; PSMA PET scan; radical prostatectomy   Disclaimer: The content of this podcast is a summary and discussion of the original publication and does not represent the views of the authors or journal. The information shared here is intended for educational purposes only and does not constitute clinical advice or recommendations. It also uses AI-assisted summaries of the original work and may or may not contain innacuracies so we encourage listeners to consult the original publication for complete details.