E9   |  12 min   |   Latest   |  Publication Source    Podcast based on: Clay R, Li K, Jin L. Metabolic Signaling in the Tumor Microenvironment. Cancers. 2025; 17(1):155. https://doi.org/10.3390/cancers17010155Type: Review  |  Publication date: Jan 6, 2025 Summary: This review article examines metabolic signalling within the tumour microenvironment (TME), focusing on how cancer cells reprogram their metabolism to promote growth and suppress anti-tumour immunity. It explores the roles of key metabolites, such as lactate, glutamine, and adenosine, in intercellular communication and the creation of a hostile TME. The article details how these metabolites affect various cell types, including immune cells and stromal cells, influencing their function and contributing to cancer progression. Finally, it discusses potential therapeutic strategies targeting these metabolic pathways to improve cancer treatment outcomes. Keywords: cancer metabolism; tumor microenvironment; immune response; oncometabolite Disclaimer: The content of this podcast is a summary and discussion of the original publication and does not represent the views of the authors or journal. The information shared here is intended for educational purposes only and does not constitute clinical advice or recommendations. It also uses AI-assisted summaries of the original work and may or may not contain innacuracies so we encourage listeners to consult the original publication for complete details.