E13   |  10 min   |   Latest   |  Publication Source    Podcast based on: Espirito Santo I, Kefleyesus A, Chilou C, Faes S, Clerc D, Hübner M, Hahnloser D, Grass F. Anal Cancer Screening: 10-Year Experience of a Specialized Outpatient Clinic. Cancers. 2025; 17(2):193. https://doi.org/10.3390/cancers17020193Type: Article  |  Publication date: Jan 9, 2025 Summary: This ten-year longitudinal study from Lausanne University Hospital analysed 537 patients attending a high-resolution anoscopy (HRA) clinic for anal cancer screening. Almost half presented with dysplastic lesions, mostly low-grade, with only a small percentage progressing to more serious conditions. High-risk HPV genotypes, detectable HIV viral load, and initial symptoms were identified as independent risk factors for advanced precancerous lesions. While no patients progressed to invasive cancer during follow-up, the findings highlight the importance of regular screening and early intervention, particularly in high-risk groups, to prevent anal cancer progression. The study also resulted in a refined institutional screening algorithm. Keywords: anal cancer; high-resolution anoscopy; HPV testing; anal dysplasia; screening; algorithm; HIV; MSM Disclaimer: The content of this podcast is a summary and discussion of the original publication and does not represent the views of the authors or journal. The information shared here is intended for educational purposes only and does not constitute clinical advice or recommendations. It also uses AI-assisted summaries of the original work and may or may not contain innacuracies so we encourage listeners to consult the original publication for complete details.