Acetazolamide + Furosemide: Boosting Diuretic Response & Fighting Alkalosis in the ICU

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Saving Lives Podcast: Critical Care w/eddyjoemd

Eddy Joe Gutierrez, MD

159 episodes

2 days ago

Saving Lives Podcast: Critical Care w/eddyjoemd is a podcast that reviews evidence-based strategies to care for the critically ill patient in the Intensive Care Unit and other topics in Medicine. It is hosted by Eddy Joe Gutierrez, MD, a board-certified critical care physician. In each episode, Dr. Gutierrez discusses the latest research and best practices in Intensive Care Medicine. He also shares his own insights and experiences as an Intensivist/Critical Care physician. The podcast is designed for healthcare professionals who want to stay up-to-date with evidence-based medicine.

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Acetazolamide + Furosemide: Boosting Diuretic Response & Fighting Alkalosis in the ICU

Saving Lives Podcast: Critical Care w/eddyjoemd

9 minutes 16 seconds

2 months ago

Acetazolamide + Furosemide: Boosting Diuretic Response & Fighting Alkalosis in the ICU

In this episode, we dive into a new pilot RCT exploring the addition of acetazolamide to furosemide in critically ill patients. We break down the study’s methods, findings, and practical implications for fluid management in the ICU. Could this inexpensive, decades-old drug be the key to sustaining diuresis and preventing metabolic alkalosis? Tune in to find out.

The Vasopressor & Inotrope Handbook

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Citation:

Maeda A, Brown A, Spano S, Chaba A, Phongphithakchai A, Hikasa Y, Pattamin N, Kitisin N, Nübel J, Nielsen B, Holmes J, Peck L, Young H, Eastwood G, Bellomo R, Neto AS. Furosemide with adjunctive acetazolamide vs furosemide only in critically ill patients: A pilot two-center randomized controlled trial. J Crit Care. 2025 Apr;86:155002. doi: 10.1016/j.jcrc.2024.155002. Epub 2024 Dec 16. PMID: 39689380.