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PCOS is a growing global issue. Its prevalence has increased in recent years and the reasons behind it are complex.
In this episode I look at its roots, causes and impact plus what we can do about it in terms of lifestyle and treatments.
Links:
Depression and PCOS: https://pmc.ncbi.nlm.nih.gov/articles/PMC10607337/
LH (luteinziing hormone): https://my.clevelandclinic.org/health/body/22255-luteinizing-hormone
LH:FSH ratio in PCOS: https://gpnotebook.com/en-GB/pages/gynaecology/polycystic-ovarian-syndrome-hormonal-measurements-in
Pancreatic function in PCOS: https://pmc.ncbi.nlm.nih.gov/articles/PMC9962893/
The gut microbiome and PCOS: https://pmc.ncbi.nlm.nih.gov/articles/PMC9998696/
The steroid synthesis pathway starting with cholesterol: https://www.researchgate.net/figure/Biosynthesis-of-steroid-hormones-from-the-cholesterol-pathway_fig1_258055538
Angelique Panagos book on hormonal balance: https://www.amazon.co.uk/Balance-Plan-Optimize-Hormonal-Health/dp/1844039447
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In this episode I look at metabolic health which is one of the most important aspects of our long term health. I look at the mechanisms and measures of metabolic health and what we can do to improve ours.
Continuous Glucose Monitoring: https://my.clevelandclinic.org/health/articles/continuous-glucose-monitoring-cgm
Hba1c: https://www.diabetes.org.uk/about-diabetes/looking-after-diabetes/hba1c#
American metabolic health stats: https://www.liebertpub.com/doi/10.1089/met.2018.0105
High fructose corn syrup; https://www.healthline.com/nutrition/why-high-fructose-corn-syrup-is-bad
Fibre in your diet: https://www.healthline.com/nutrition/why-is-fiber-good-for-you
Exercise and metabolic health: https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2024.1365761/full
Metabolic health and Alzheimer's risk: https://pmc.ncbi.nlm.nih.gov/articles/PMC10001958/
Non-communicable diseases: https://www.who.int/news-room/fact-sheets/detail/noncommunicable-diseases
Save your life in slow motion and those of others by subscribing now and sharing. Thank you for listening and for your support. It means a lot to me.
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In this episode I cover my own personal tips from the view point of a GP and lifestyle medicine doctor. Gut symptoms Around 86% of us in the UK have experienced gut symptoms at some point. My tips are simple, for everyone and hopefully make sense.
Parasympathetic drive for digestion: https://www.livescience.com/parasympathetic-nervous-system-rest-and-digest
Digestive enzymes: https://www.webmd.com/diet/what-are-digestive-enzymes
Blue Zones eating habits: https://www.bluezones.com/2020/07/blue-zones-diet-food-secrets-of-the-worlds-longest-lived-people/
Mediterranean Diet: https://my.clevelandclinic.org/health/articles/16037-mediterranean-diet
Late night eating: https://hms.harvard.edu/news/late-night-eating-impact
Time restricted eating: https://www.healthline.com/nutrition/time-restricted-eating
Ileo-caecal valve issues: https://www.carygastro.com/blog/what-are-the-symptoms-of-a-faulty-ileocecal-valve
Hydration and the gut (an academic paper): https://www.sciencedirect.com/science/article/pii/S2589004224011258
Buy my book The Health Fix now: https://www.amazon.co.uk/Health-Fix-Dr-Ayan-Panja/dp/1914239326/ref=tmm_pap_swatch_0
Save your life in slow motion and those of others by subscribing now and sharing. Thank you for listening and for your support. It means a lot to me.
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Chronic inflammation is a key process which is linked to almost all non-communicable disease. In this episode I look at how it arises and why it is so harmful.
Links:
Age-related end glycation products: https://www.healthline.com/nutrition/advanced-glycation-end-products#what-they-are
'Leaky gut’ syndrome: https://pmc.ncbi.nlm.nih.gov/articles/PMC8305009/
Depression as an inflammatory condition: https://www.sciencedirect.com/science/article/pii/S1043661824002676
Probitoics after antibiotics?: https://www.bbc.com/future/article/20190124-is-it-worth-taking-probiotics-after-antibiotics
Diabetes and inflammation: https://www.webmd.com/diabetes/inflammation-and-diabetes
Inflammation from toxins (metals and brain inflammation): https://www.sciencedirect.com/science/article/abs/pii/S2468202021000127
Anti-inflammatory diet: https://www.hopkinsmedicine.org/health/wellness-and-prevention/anti-inflammatory-diet
Fibre: https://dremilyleeming.substack.com/p/is-fibre-the-missing-link-to-true
Omega-3 and inflammation: https://pubmed.ncbi.nlm.nih.gov/37606147/
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What do surgery and psychiatry have in common? They are both demanding specialties, occasionally of last resort, that save lives acutely and help people back to better health.
Links
Antipsychotic drug discovery: https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2022.903156/full
Pyrrole Disorder: https://www.healthline.com/health/pyrrole-disorder#diagnosis
Rationing in the NHS: https://www.kingsfund.org.uk/insight-and-analysis/blogs/nhs-rationing-under-the-radar
An example of risks vs benefit in surgery: https://www.neurosurgeonsofnewjersey.com/blog/spinal-fusion-surgery-risks/
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There are so many posts, papers and publications about the vagus nerve.
In this episode I look at why it’s so popular and whether it really can be a key to future treatments with advances vagus nerve stimulation.
Links:
Quick overview: https://www.mayoclinic.org/tests-procedures/vagus-nerve-stimulation/about/pac-20384565
Polyvagal Theory: https://www.polyvagalinstitute.org/whatispolyvagaltheory
The Great Nerve: https://www.amazon.co.uk/Great-Nerve-Science-Harness-Reflexes/dp/059371699X
Research on the vagus and rheumatoid arthritis: https://pubmed.ncbi.nlm.nih.gov/27382171/
Ear stimulation: https://medicine.ouhsc.edu/news/article/ear-clip-stimulation-of-vagus-nerve-shows-promise-as-pots-treatment-according-to-ou-college-of-medicine-study
Vasovagal attacks: https://my.clevelandclinic.org/health/diseases/23325-vasovagal-syncope
Crohn’s Disease and vagus nerve stimulation: https://pubmed.ncbi.nlm.nih.gov/32515156/
Vagus nerver and inflammation: https://bioelecmed.biomedcentral.com/articles/10.1186/s42234-022-00100-3
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Medicine is an inexact science. My patients who are engineers find it frustrating that there is so much conjecture and educated guess work in medicine. But this episode highlights why diagnoses can take time. It’s a mix of detective work, bias and listening to the patient story.
Links:
Chilblains: https://www.mayoclinic.org/diseases-conditions/chilblains/diagnosis-treatment/drc-20351103
STI and painful knee: https://www.medicalnewstoday.com/articles/gonococcal-arthritis
Carpal tunnel syndrome: https://orthoinfo.aaos.org/en/diseases--conditions/carpal-tunnel-syndrome/
Psychodermatology (the mind-skin link): https://www.psychodermatology.co.uk/
Liver inflammation and glandular fever: https://www.healthline.com/health/mono-hepatitis
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Not a week goes by in practice where I don’t see a patient who hasn’t collapsed or had a dizzy spell.
There are so many reasons for this, some preventable, some not. I look at some of the syndromes that lead to these issues.
Links:
Fainting: https://www.healthline.com/health/fainting#causes
Pseudoseizures (non-eplieptic seizures): https://my.clevelandclinic.org/health/diseases/24517-psychogenic-nonepileptic-seizure-pnes
Absence seizures: https://www.mayoclinic.org/diseases-conditions/petit-mal-seizure/symptoms-causes/syc-20359683
Epilepsy and driving: https://www.gov.uk/epilepsy-and-driving
BPPV (a type of vertigo): https://my.clevelandclinic.org/health/diseases/11858-benign-paroxysmal-positional-vertigo-bppv
Patient perspective of Mal de Debarquement syndrome: https://www.rarediseaseday.org/heroes/a-uk-patient-perspective-on-mal-de-debarquement-syndrome/
Heartblock: https://www.nhs.uk/conditions/heart-block/
Gluten ataxia: https://www.medicalnewstoday.com/articles/320730
Proprioception: https://my.clevelandclinic.org/health/articles/proprioception
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5-15% of GP consultations are linked to tiredness. And the number is growing. In this episode I look at common and rarer reasons for tiredness.
Hydration - if you’re feeling thirsty you’re partly dehydrated:
https://www.nhsinform.scot/illnesses-and-conditions/nutritional/dehydration/
Sleep apnoea: https://www.mayoclinic.org/diseases-conditions/sleep-apnea/symptoms-causes/syc-20377631
Breathing to help some root causes of fatigue: https://buteykoclinic.com/blogs/buteyko-breathing-technique/buteyko-breathing-technique
Mycotoxin illness: https://www.parsleyhealth.com/blog/mold-toxicity-symptoms/
Co-enzyme Q10: https://bjcardio.co.uk/2015/10/coenzyme-q10-and-cardiovascular-disease-an-overview/
Antibiotic tiredness: https://www.medicalnewstoday.com/articles/do-antibiotics-make-you-tired
Burnout: https://mentalhealth-uk.org/burnout/
Save your life in slow motion and those of others by subscribing now and sharing. Thank you for listening and for your support. It means a lot to me.
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Teenage and adolescent health offers us a glimpse into the future health of the world. The Lancet Commission wrote a report in 2016 and have recently written a follow up which paints a slightly concerning picture.
In this episode I look at health in this group of people, the challenges they face and what, if anything, can be done about it.
Links:
The Lancet Commission report summary: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00863-3/fulltext
Barriers to healthcare for adolescents: https://pmc.ncbi.nlm.nih.gov/articles/PMC8070789/
Global numbers: https://www.who.int/news-room/fact-sheets/detail/adolescents-health-risks-and-solutions
Omega-3 and brain health: https://pubmed.ncbi.nlm.nih.gov/35960396/
Climate Stress: https://pmc.ncbi.nlm.nih.gov/articles/PMC10154789/
Free tips from Annette Du Bois (teenage coach): https://www.champs-academy.co.uk/free-help-and-support/
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In this episode I look at our health compared to 100 years ago. I was pleasantly surprised at some similarities having stumbled across something online but then also appreciate that we live in a different world now.
Links:
Donald Moore’s health habits in 1925: https://archive.org/details/health.habits.moore.1925/page/n1/mode/2up
Adventist health: https://www.bluezones.com/explorations/loma-linda-california/
Health in the 1920s: https://www.encyclopedia.com/social-sciences/culture-magazines/1920s-medicine-and-health-overview
Tech neck: https://sharpphysiotherapy.co.uk/the-hidden-dangers-of-tech-neck/
Pesticides and human health: https://pmc.ncbi.nlm.nih.gov/articles/PMC11426366/
Mycotoxin illness: https://pmc.ncbi.nlm.nih.gov/articles/PMC8619365/
Toxic productivity: https://hbr.org/2024/11/lets-end-toxic-productivity
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In the UK, there is much discussion around assisted dying with a bill that is being voted on in government at the moment.
In this episode I look at the ethics around it and what it might mean on an individual and societal level.
Palliative Care: https://www.nhs.uk/tests-and-treatments/end-of-life-care/what-it-involves-and-when-it-starts/
Dr Florian Willett’s death: https://www.independent.co.uk/news/world/europe/suicide-pod-activist-euthanasia-sarco-b2762514.html
Locked-in syndrome: https://my.clevelandclinic.org/health/diseases/22462-locked-in-syndrome-lis
How assisted dying works in The Netherlands: https://www.theguardian.com/lifeandstyle/2015/sep/11/assisted-dying-dutch-end-of-life-netherlands-unbearable-suffering
Talking about death and dying: https://www.hospiceuk.org/information-and-support/death-and-dying-what-expect/about-death-and-dying
The Humanists view: https://humanists.uk/2023/10/03/six-reasons-we-need-an-assisted-dying-law/
The current state of affairs in the UK regarding the assisted dying bill: https://www.bbc.co.uk/news/articles/c5y5d2g3wgxo
My new website: https://drayan.co.uk/
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Fasting is a hot but contentious topic.
It has been practised for thousands of years and is now
purported to be a way of tackling or preventing certain metabolic diseases.
In this episode I look at the pros, cons and mechanisms of fasting.
Links:
Historical perspectives of fasting: https://pmc.ncbi.nlm.nih.gov/articles/PMC8838777/
Time restricted feeding in mice (Sachin Panda): https://pmc.ncbi.nlm.nih.gov/articles/PMC3491655/
Further study (see first image for feeding habits): https://www.sciencedirect.com/science/article/pii/S1550413114004987
5:2 diet summary: https://www.healthline.com/nutrition/the-5-2-diet-guide
Prolonged fasting: https://pubmed.ncbi.nlm.nih.gov/37377031/
Fasting and autophagy: https://my.clevelandclinic.org/health/articles/24058-autophagy
The flip side - analysis of a study that found a increased link to heart disease from fasting: https://www.bhf.org.uk/informationsupport/heart-matters-magazine/news/behind-the-headlines/intermittent-fasting#
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Every week or so you will see and article about one or more of these topics.
Maybe you have tried them or do them regularly. In the episode I look at the science and thinking behind them all.
Links:
Cold water exposure - a paper: https://pmc.ncbi.nlm.nih.gov/articles/PMC9518606/
Vagus nerve stimulation: https://my.clevelandclinic.org/health/treatments/17598-vagus-nerve-stimulation
Hyperbaric oxygen: https://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/hyperbaric-oxygen-therapy
Saunas and potential benefits (academic paper): https://www.sciencedirect.com/science/article/pii/S0531556521002916#s0180
High Protein Diet: https://www.healthline.com/nutrition/high-protein-diet-plan
Buy my book THE HEALTH FIX now: https://www.amazon.co.uk/Health-Fix-Dr-Ayan-Panja/dp/1914239326/ref=tmm_pap_swatch_0
My new website:
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Prescribing Lifestyle Medicine is a course I run with Dr Rangan Chatterjee that has been going for 8 years now.
It was the first course of its kind in the UK and in this episode I look at a recap of our recent conference, what has changed in lifestyle medicine over the years and the latest science.
Links:
Dr Emily Leeming: https://www.emilyleeming.com/
Dr Rob Lustig: https://robertlustig.com/
Dr Kiran Sodha: https://www.drsodha.co.uk/
Dr Nathaniel Roocroft’s work: https://www.royalnavy.mod.uk/news/2023/november/23/20231123-uk-flagship-pioneers-largest-ever-mental-and-physical-health-drive-at-sea
Dr Madhvi Joshi: https://www.linkedin.com/in/madhvi-joshi-419b71353/
Depression as an inflammatory disease: https://pubmed.ncbi.nlm.nih.gov/38826138/
Gut-brain axis and the role of the microbiome in neurodegeneration: https://www.nature.com/articles/s41392-024-01743-1
Fibre benefits: https://www.healthline.com/nutrition/why-is-fiber-good-for-you
Weight loss drugs hold key to longer life?: https://www.thetimes.com/uk/healthcare/article/golden-age-of-medicine-weight-loss-drugs-seen-as-key-to-longer-life-3wblnx3j6#
Prescribing Lifestyle Medicine:
https://www.practiceunbound.org.uk/product/prescribinglifestylemedicine/home
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Ayurvedic Medicine is thousands of years old. It has a systems based approach which can be personalised and its methods are based on careful observation and the interconnectedness of human beings and our relation to our environment. There has also been caution around some treatments which can cause harm which I cover in this episode.
A quick summary of Ayurvedic Medicine: https://www.nccih.nih.gov/health/ayurvedic-medicine-in-depth
The doshas: https://www.healthline.com/nutrition/vata-dosha-pitta-dosha-kapha-dosha
Pulse diagnosis: https://www.healingholidays.com/blog/pulse-diagnosis-in-ayurveda
Liver Disease in 14 year old: https://timesofindia.indiatimes.com/city/kochi/liver-failure-in-14-year-old-kerala-girl-leads-to-traditional-vs-modern-medicine-debate/articleshow/94822613.cms
Ayurvedic herbs: https://www.healthline.com/nutrition/ayurvedic-herbs
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It’s easy to race through life without thinking that we need to do some inner work on ourselves but more often than not it catches up with us at some point.
In this episode I look at why it’s important and go through a basic inner child exercise to get you started.
Links:
A beginner’s guide to inner child work: https://www.healthline.com/health/mental-health/inner-child-healing#listen
Some books which covers this and a lot more:
How to do the work by Nicole LePera: https://www.amazon.co.uk/How-Do-Work-Recognise-Patterns/dp/1409197743
The book you wish your parents had read: https://www.amazon.co.uk/Book-Wish-Your-Parents-Read/dp/0241251028
Arian Samouie's work: https://ariansamouie.com/
Why is everyone working on their inner child?: https://time.com/6268636/inner-child-work-healing/
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Symptoms are often hard to interpret with the amount of data and tools that are out there these days.
In this episode I look at innocuous symptoms that can creep up on us over a long time but could be harbinger of an underlying condition.
Raynaud’s Phenomenon: https://www.hopkinsmedicine.org/health/conditions-and-diseases/raynauds-phenomenon
Fungal nails: https://patient.info/infections/fungal-nail-infection-tinea-unguium
Nitric oxide foods: https://www.webmd.com/diet/healthy-foods-nitric-oxide
FIT testing for bowel cancer: https://www.faecal-immunochemical-test.co.uk/healthcare-professionals/about-faecal-immunochemical-testing/
Body odour: https://my.clevelandclinic.org/health/symptoms/17865-body-odor
Phaeochromocytoma: https://www.mayoclinic.org/diseases-conditions/pheochromocytoma/symptoms-causes/syc-20355367#
Unexplained weight loss: https://my.clevelandclinic.org/health/symptoms/unexplained-weight-loss
Rash - acanthosis nigricans: https://www.nhs.uk/conditions/acanthosis-nigricans/
Buy The Health Fix now: https://www.amazon.co.uk/Health-Fix-Dr-Ayan-Panja/dp/1914239326/ref=tmm_pap_swatch_0
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There isn’t a week that I don’t hear the phrase ‘work-life balance’. In this episode I look at what it means, how it has changed over the years and what we can do to try to get it right.
What is work-life balance?: https://www.forbes.com/sites/maurathomas/2022/07/26/what-does-work-life-balance-even-mean/
Severance: https://www.imdb.com/title/tt11280740/
Womens Liberation and WLB: https://pmc.ncbi.nlm.nih.gov/articles/PMC4079063/#:
The Great Resignation: https://hbr.org/2022/03/the-great-resignation-didnt-start-with-the-pandemic
Freelancing pros and cons: https://medium.com/@mrmunifali/the-5-pros-and-cons-of-freelance-work-15e1dbb375c6
Why Google perks may not be what good working life is about: https://www.cnbc.com/2019/04/18/google-amazon-microsoft-perks-dont-matter-this-is-what-keeps-talented-people-from-quitting.html
Work is good for us: https://www.bmj.com/content/353/bmj.i2191
Boiling frogs: https://www.psychologytoday.com/gb/blog/lessons-from-a-burnt-out-psychologist/202406/the-boiling-frog-syndrome-a-metaphor-for-burnout
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In this episode I have saved up questions from the last 6 months and decided to tackle them head on. From whether you should get a DNA analysis to why some people think fibre is bad for you - it’s in this ep!
DNA analyses - a view point https://www.theguardian.com/science/2017/jul/23/what-i-learned-from-home-dna-test-kits-are-they-accurate-or-worthwhile
SNPs: https://medlineplus.gov/genetics/understanding/genomicresearch/snp/
Genetic screening via health professionals: https://www.nhs.uk/conditions/predictive-genetic-tests-cancer/
MCM6: https://medlineplus.gov/download/genetics/gene/mcm6.pdf
The genes of Alzheimer’s Disease: https://www.nia.nih.gov/health/alzheimers-causes-and-risk-factors/alzheimers-disease-genetics-fact-sheet
Alcohol and WHO advice: https://www.who.int/europe/news/item/04-01-2023-no-level-of-alcohol-consumption-is-safe-for-our-health
Chronic fatigue syndrome: https://www.healthline.com/health/chronic-fatigue-syndrome
Long Covid YouTube channel: https://www.youtube.com/@LCCWYCD
Organic food - the dirty dozen and the clean fifteen: https://www.ewg.org/foodnews/clean-fifteen.php
Fibre bad for us? (A dissection of this argument): https://biolayne.com/articles/research/paul-saladino-on-joe-rogan-experience-hype-vs-evidence/
Dr Emily Leeming on fibre: https://dremilyleeming.substack.com/p/is-fibre-the-missing-link-to-true
My case for generalism: https://www.youtube.com/watch?v=ST6XEDcD_C4
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