Health screeners, patient navigators, and promotoras often are the first line of defense against the spread of disease in healthcare settings, as they deliver patient assessment and education services in hospitals, clinics, cancer centers, and in the community. In this episode, Dolores Garcia, a community health worker at the Institute for Health Promotion Research at UT Health San Antonio; Dr. Judith Flores, MD FAAP, CHCQM, a board-certified pediatrician and Clinical Associate Professor at The New York University School of Medicine; and Dr. Ricardo Correa, MD, Es. D, FACP, FAPCR, CMQ, an associate professor of medicine for the University of Arizona College of Medicine Phoenix, discuss the role of screeners, navigators, community health workers, and promotoras in infection control and the challenges they face. Additionally, as part of the Centers for Disease Control & Prevention’s Project Firstline, they discuss infection control strategies and resources that screeners, navigators, and promotoras can use to minimize the spread of COVID-19 and other diseases.