In this next episode in the movement disorders and Parkinson’s disease series, we begin with a brief overview of the mechanisms of action of the medications used to treat Parkinson’s disease, before focusing on five common and important ward dilemmas encountered in the management of patients with Parkinson’s disease: (1) the patient is unable to take their oral antiparkinsonian medications, (2) the patient is psychotic or delirious, (3) the patient has autonomic instability/dysregulation with orthostatic hypotension +/- supine nocturnal hypertension, (4) the patient is frozen/in an ‘off’ crisis, and (5) the much-feared Parkinson-hyperpyrexia syndrome. We discuss pragmatic ways to tackle each of these problems, coloured with analogies and detailed explanations to make the content understandable in a structured manner (and hopefully also memorable!). This episode is suitable for anyone caring for patients with Parkinson’s disease, although it should be especially useful for junior doctors covering the wards on evening/night and weekend shifts (and medical students also about to find themselves in this position)!

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