In this episode of the Research Forward Podcast, host David Mayo sits down with Dr. Eleanor Raffan, veterinary surgeon and geneticist at the University of Cambridge, to explore the surprising genetic links between obesity in dogs and humans. Through her groundbreaking work with pet Labradors and other breeds, Dr. Raffan reveals how genes like POMC and D1B influence appetite, metabolism, and weight gain—offering insights that challenge the conventional wisdom that obesity is simply a matter of willpower. Her research not only highlights the biological complexity of obesity but also underscores the shared health challenges between humans and their canine companions. Dr. Raffan also discusses the ethical and practical importance of studying dogs in their home environments rather than in kennels, and how her team’s findings are reshaping how veterinarians and pet owners approach obesity prevention. From the role of polygenic risk scores to the impact of neutering on appetite, this episode dives deep into the science of obesity while advocating for compassion and understanding—both for pets and people. Whether you're a dog lover, a health professional, or just curious about the genetics of weight, this conversation offers valuable perspectives on a growing global issue.