In this episode of Relatable Wisdom, I sit down with Jamey Maniscalco, a neuroscientist and founder of Manifest Wellness, who brings both scientific expertise and deeply personal experience to the table. We dive into Jamey’s favorite quote from Nietzsche: “He who has a why to live can bear almost any how.” Jamey shares candid stories about walking away from a lucrative but unfulfilling consulting career in pursuit of purpose, rediscovering happiness and meaning through teaching—even when it required a drastic lifestyle change. Together, we unpack how knowing your “why” fuels resilience through tough times and keeps you motivated when the “how” gets challenging. Jamey also offers real-world tools for finding your own why, from unplugging from distractions to trying new experiences. Whether you’re questioning your work, searching for direction, or simply want to bring intention into everyday projects, this episode is full of relatable insights and practical inspiration for anyone seeking to live with more purpose.
Connect With Jamey Maniscalco
Website: https://manifestwellness.co
Manifest Wellness: https://manifestwellness.co
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Chapters
00:00 Introduction And Welcome
00:43 Meet Jamey Maniscalco
01:13 Sharing Favorite Quote
01:45 Unpacking The Nietzsche Quote
02:42 Early Career And Purpose Struggles
03:55 Burnout And Career Change
04:45 Rediscovering Meaning In Academia
05:50 Defining A Personal Why
06:24 Why Your Job May Change
07:20 How The Why Drives Resilience
08:42 Finding Your Why
09:42 Quiet Reflection And Self-Knowledge
10:56 Self-Assessment And Honest Feedback
13:10 Trying New Experiences
14:29 Overcoming Fear Of Imperfection
15:32 Learning From Failed Attempts
16:38 On Not Knowing Your Strengths
17:25 Encouraging Self-Discovery
18:25 The Why Behind Projects
19:15 Anchoring Values In Everyday Actions
20:26 Mindset And Perspective Shifts
21:45 Practicing Glass-Half-Full Thinking
23:13 Perception Shapes Reality
24:34 Visualizing The Future
24:45 Closing Thoughts And Goodbye
25:06 Where To Find Jamey
25:35 Final Wrap Up
