A narrative podcast series hosted by journalist Surani Fernando that goes beyond the headlines to explore how biotech companies are really built — from bold ideas and impressive fundraises to the science that could reshape healthcare. Surani speaks with founders, CEOs, investors, and experts to uncover origin stories, company missions, and the challenges of bringing ambitious discoveries to market. Through thoughtful, independent reporting, Raising Biotech examines what it really takes to turn breakthroughs into lasting impact for patients and the industry.
For guest or sponsor pitches, please get in touch with Surani Fernando on LinkedIn or email raisingbiotech@gmail.com.
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A narrative podcast series hosted by journalist Surani Fernando that goes beyond the headlines to explore how biotech companies are really built — from bold ideas and impressive fundraises to the science that could reshape healthcare. Surani speaks with founders, CEOs, investors, and experts to uncover origin stories, company missions, and the challenges of bringing ambitious discoveries to market. Through thoughtful, independent reporting, Raising Biotech examines what it really takes to turn breakthroughs into lasting impact for patients and the industry.
For guest or sponsor pitches, please get in touch with Surani Fernando on LinkedIn or email raisingbiotech@gmail.com.
S1, E6: Alltrna and tRNA therapeutics for rare genetic diseases with CEO Michelle Werner and rare diseases expert Dr David Weinstein
Raising Biotech
30 minutes
1 year ago
S1, E6: Alltrna and tRNA therapeutics for rare genetic diseases with CEO Michelle Werner and rare diseases expert Dr David Weinstein
In this episode of Raising Biotech, Surani explores the untapped world of tRNA therapeutics with Flagship Pioneering-founded company Alltrna. The company raised $109 million in a series B in August 2023. Surani talks to CEO Michelle Werner about the inception of Alltrna, the company's tRNA therapeutic thesis and her journey to the role. She also talks about the company's plans to study its technology in rare genetic liver diseases and the potential to accelerate clinical trials with the use of basket trials. Dr David Weinstein, a rare diseases pediatrician and owner of Weinstein Rare Disease and Clinical Development Consulting also joins the podcast to give his take on the potential of tRNA therapeutics to serve thousands of diseases. He gives his thoughts on the company's mission, potential clinical trial challenges ahead and how the therapeutics might fit into the treatment paradigm.
Timestamps:
01:58 - Background of Alltrna and tRNA therapeutics for rare genetic diseases
06:00 - Company formation under Flagship and Michelle's personal backstory
11:35 - Focussing on stop-codon diseases of the liver for first clinical trials
12:55 - Dr Weinstein talks about tRNA therapies for rare genetic diseases
16:55 - The use of basket trials to accelerate clinical trials
18:30 - Efficacy and safety considerations & regulatory pathway
21:45 - How tRNA therapies would fit into the treatment paradigm
24:05 - Potential for tRNA in other genetic diseases beyond the liver
26:00 - Alltrna's future pipeline and business strategy
For any comments, questions, feedback or suggestions you can connect directly with Surani Fernando on LinkedIn or email: raisingbiotech@gmail.com
Music composed by: Yrii Semchyshyn (Coma Media)
Hosted on Acast. See acast.com/privacy for more information.
Raising Biotech
A narrative podcast series hosted by journalist Surani Fernando that goes beyond the headlines to explore how biotech companies are really built — from bold ideas and impressive fundraises to the science that could reshape healthcare. Surani speaks with founders, CEOs, investors, and experts to uncover origin stories, company missions, and the challenges of bringing ambitious discoveries to market. Through thoughtful, independent reporting, Raising Biotech examines what it really takes to turn breakthroughs into lasting impact for patients and the industry.
For guest or sponsor pitches, please get in touch with Surani Fernando on LinkedIn or email raisingbiotech@gmail.com.
