Sickle cell disease (SCD) patients are at risk of developing multiple complications from transfusions, including alloimmunization to red blood cell antigens, delayed hemolytic transfusion reactions and hyperhemolysis syndrome (HHS). While HHS is a rare complication of repeat blood transfusions in patients with SCD, clinicians and the laboratory have important roles in its detection and management.In this podcast, Wally R. Smith, MD, the inaugural Florence Neal Cooper Smith Professor of Sickle Cell Disease at Virginia Commonwealth University shares insights to screening for and managing HHS.   About Our Speaker:  Wally R. Smith, MD, is an experienced implementation scientist and expert in clinical and health services research in sickle cell disease (SCD). He serves as Vice Chair for Research of the Division of General Internal Medicine at Virginia Commonwealth University (VCU) and was Scientific Director of the Center on Health Disparities at VCU. Dr. Smith has authored over 100 publications and served as an investigator on over 50 grants and contracts. He has been principal investigator on 26 federal or foundation-funded grants and contracts including: Pain in Sickle Cell Epidemiology Study (PiSCES), the largest and most detailed adult cohort that changed our understanding of SCD pain in adults and, since 2012, Start Healing in Patients with Hydroxyurea, the first-ever randomized controlled trial of implementation science in SCD.