Decoding Aging and the Environment with Cornelia van Duijn

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Proteomics in Proximity

Olink Proteomics

26 episodes

1 month ago

Proteomics in Proximity discusses the intersection of proteomics with genomics for drug target discovery, the application of proteomics to reveal disease biomarkers, and current trends in using proteomics to unlock biological mechanisms. Co-hosted by Olink's Dale Yuzuki, Cindy Lawley and Sarantis Chlamydas.

Life Sciences

Science

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Life Sciences

Science

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Decoding Aging and the Environment with Cornelia van Duijn

Proteomics in Proximity

56 minutes

11 months ago

Decoding Aging and the Environment with Cornelia van Duijn

Welcome to the Olink® Proteomics in Proximity podcast!

Below are some useful resources mentioned in this episode:

Olink tools and software

Olink® Explore 3072, the platform utilized by the UK Biobank to measure ~3000 proteins in plasma: https://olink.com/products-services/explore/

Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, measuring 5400+ proteins simultaneously with a streamlined workflow and industry-leading specificity: https://olink.com/products-services/exploreht/

UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to date, https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies

Research articles

The support of human genetic evidence for approved drug indications

Matthew R Nelson et al, Nature Genetics 2015

https://www.nature.com/articles/ng.3314

Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations

M. Austin Argentieri et al, Nature Medicine 2024

https://www.nature.com/articles/s41591-024-03164-7

Plasma protein-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems

Ludger J.E. Goeminne et al, Cell Metabolism 2024, in press

https://www.sciencedirect.com/science/article/abs/pii/S1550413124004017?via%3Dihub

Plasma proteomic associations with genetics and health in the UK Biobank