Aghajanian, H., Kimura, T., Rurik, J.G. et al. Targeting cardiac fibrosis with engineered T cells. Nature 573, 430–433 (2019). https://doi.org/10.1038/s41586-019-1546-z Published: 11 September 2019 by Jonathan A. Epstein Group at UPenn Abstract: Fibrosis is observed in nearly every form of myocardial disease1. Upon injury, cardiac fibroblasts in the heart begin to remodel the myocardium by depositing excess extracellular matrix, resulting in increased stiffness and reduced compliance of ...
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Aghajanian, H., Kimura, T., Rurik, J.G. et al. Targeting cardiac fibrosis with engineered T cells. Nature 573, 430–433 (2019). https://doi.org/10.1038/s41586-019-1546-z Published: 11 September 2019 by Jonathan A. Epstein Group at UPenn Abstract: Fibrosis is observed in nearly every form of myocardial disease1. Upon injury, cardiac fibroblasts in the heart begin to remodel the myocardium by depositing excess extracellular matrix, resulting in increased stiffness and reduced compliance of ...
Selective inhibition of stromal mechanosensing suppresses cardiac fibrosis
Podcasts for Cardiac Researcher and Cardiologists
17 minutes
6 months ago
Selective inhibition of stromal mechanosensing suppresses cardiac fibrosis
Cho, S., Rhee, S., Madl, C.M. et al. Selective inhibition of stromal mechanosensing suppresses cardiac fibrosis. Nature (2025). https://doi.org/10.1038/s41586-025-08945-9 Published: 30 April 2025 from Joseph C. Wu Group at Stanford University, School of Medicine Abstract: Matrix-derived biophysical cues are known to regulate the activation of fibroblasts and their subsequent transdifferentiation into myofibroblasts, but whether modulation of these signals can suppress fibrosis in intact tissu...
Podcasts for Cardiac Researcher and Cardiologists
Aghajanian, H., Kimura, T., Rurik, J.G. et al. Targeting cardiac fibrosis with engineered T cells. Nature 573, 430–433 (2019). https://doi.org/10.1038/s41586-019-1546-z Published: 11 September 2019 by Jonathan A. Epstein Group at UPenn Abstract: Fibrosis is observed in nearly every form of myocardial disease1. Upon injury, cardiac fibroblasts in the heart begin to remodel the myocardium by depositing excess extracellular matrix, resulting in increased stiffness and reduced compliance of ...
