This episode covers practical, evidence-informed strategies for reversing anticoagulant and antiplatelet medications in critical bleeding scenarios, including intracerebral hemorrhage. We review reversal protocols for warfarin, dabigatran, and Factor Xa inhibitors, and discuss the roles of PCC, FFP, DDAVP, and tranexamic acid. Key pitfalls in reversal therapy are examined, along with guidance on tailoring interventions to individual patients.