A landmark cancer treatment program is underway in Australia. Known as Prospect, the study is opening up new, potentially life-saving treatment pathways for 23,000 Australians with advanced, incurable or an earlier diagnosis of poor prognosis cancers. We talk to Prof Rob Lindeman and Louise Carey about the vital services NSW Health Pathology is providing for Prospect, from genomic sequencing to blood collection and supply of diagnostic tissue. We also hear from Matthew Webster, an engineer whose life was changed forever 10 years ago when he was diagnosed with a rare cancer, who explains how personalised cancer treatment has made all the difference. For more information on the Prospect study go to https://www.omico.com.au/prospect/