Welcome to Pathocast In Review – S1. Ep1: Targeting precursor B Cells for bnAbs | Antibiotics to protect uncircumsed from HIV.
In our premiere episode, we dive into the cutting edge of HIV science. Join us as we explore the latest findings on the quest for an effective HIV vaccine—specifically, how broadly neutralising antibodies are induced by vaccines by targeting extremely rare precursor B cells.

We also unpack new research into how antibiotics might offer an unexpected tool in HIV prevention for men who opt not to undergo circumcision. It's a nuanced discussion at the intersection of immunology, microbiota, and global health strategy.

Papers in Review:

1. Diverse priming outcomes under conditions of very rare precursor B cells (DOI: 10.1016/j.immuni.2025.03.003).

2. Impact of antimicrobials on penile HIV susceptibility and immunology in uncircumcised men: A randomized phase 1/2 clinical trial (DOI: 10.1016/j.xcrm.2024.101705).

Moderator: Sherazaan Ismail

Panelists: Sonwa Dzanibe (@sonwa_dzanibe) and Adijat Jimoh (@deejah_deej)

Production: Zd Creations

Creator: Immun-Vir JC

Music: iLethu (@Mphephethwa_sa)