Silent Shifts: How Early Life Antibiotics and Hidden HIV Cells Shape Immunity

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Pathocast in Review

Zd_creation

5 episodes

1 day ago

The Pathocast in Review adopts a journal club format to critically dissect the latest research in immunology, virology, and infectious disease. Join our panellist as they deep-dive into recently published studies in a roundtable discussion. Leaving no stone unturned—we cover groundbreaking work across basic science, translational research, and clinical studies that are pushing the boundaries of the field. follow us on: Instagram - instagram.com/pathocast_review Tiktok - www.tiktok.com/@pathocast_rev

Life Sciences

Science

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Life Sciences

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Silent Shifts: How Early Life Antibiotics and Hidden HIV Cells Shape Immunity

Pathocast in Review

48 minutes 59 seconds

3 months ago

Silent Shifts: How Early Life Antibiotics and Hidden HIV Cells Shape Immunity

Welcome to Pathocast In Review – S1. Ep2 - Silent Shifts: How Early Life Antibiotics and Hidden HIV Cells Shape Immunity. In this second episode, we explore the far-reaching consequences of early-life antibiotic use. Beyond driving the emergence of antibiotic resistance, these interventions disrupt the developing microbiota—blunting vaccine responses and leaving infants more vulnerable to infections. We also dive into cutting-edge research using a mouse model system to track latently HIV-infected cells. Through the HIV-1-Induced Lineage Tracing (HILT) system, we examine whether these persistent cells express distinguishing markers that could make them identifiable—and ultimately, targetable—for eradication.Papers in Review:

1. Bifidobacteria support optimal infant vaccine responses (DOI: ⁠10.1038/s41586-025-08796-4).

2. Tracking HIV persistence across T cell lineages during early ART-treated HIV-1 infection using a reservoire-marking humanized mouse model (DOI: 10.1038/s41467-025-57368-7).

Moderator: Sonwa Dzanibe (@sonwa_dzanibe)Panelists: Anna Happel and Cheval Sookram (@chevalsookram)

Production: Zd Creations

Creator: Immun-Vir JC

Music: iLethu (@Mphephethwa_sa)