Immune Harmony and Disruption: IgA in the Gut, and Gestational Diabetes Risks GBS

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Pathocast in Review

Zd_creation

5 episodes

1 day ago

The Pathocast in Review adopts a journal club format to critically dissect the latest research in immunology, virology, and infectious disease. Join our panellist as they deep-dive into recently published studies in a roundtable discussion. Leaving no stone unturned—we cover groundbreaking work across basic science, translational research, and clinical studies that are pushing the boundaries of the field. follow us on: Instagram - instagram.com/pathocast_review Tiktok - www.tiktok.com/@pathocast_rev

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Life Sciences

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Immune Harmony and Disruption: IgA in the Gut, and Gestational Diabetes Risks GBS

Pathocast in Review

53 minutes 12 seconds

2 months ago

Immune Harmony and Disruption: IgA in the Gut, and Gestational Diabetes Risks GBS

Welcome to Pathocast In Review – S1. Ep3 - Immune Harmony and Disruption: IgA in the Gut, and Gestational Diabetes Risks GBS. The third episode explores how secretory IgA shapes intestinal immune balance by limiting viral colonisation, and how its absence triggers a compensatory expansion of CD8 T cells. We also examine how gestational diabetes disrupts maternal immunity and alters the vaginal microbiota, amplifying the harmful effects of Group B Streptococcus colonisation during pregnancy.

Papers in Review:1. Immunoglobulin A controls intestinal virus colonization to preserve immune homeostasis (DOI: ⁠⁠10.1016/j.chom.2025.03.004).

2. Gestational diabetes augments group B Streptococcus infection by disrupting maternal immunity and the vaginal microbiota (DOI: ⁠⁠⁠⁠10.1038/s41467-024-45336-6 ⁠).

Moderator: Wealth Okete (@wealthokete_)

Panelists: Rachael Gachogo and Nelisa Makeleni (@nelly_saciar ⁠)

Production: Zd Creations

Creator: Immun-Vir JC

Music: iLethu (@Mphephethwa_sa)