Beyond the Years: How HIV and Obesity Rewire Ageing

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Pathocast in Review

Zd_creation

5 episodes

1 day ago

The Pathocast in Review adopts a journal club format to critically dissect the latest research in immunology, virology, and infectious disease. Join our panellist as they deep-dive into recently published studies in a roundtable discussion. Leaving no stone unturned—we cover groundbreaking work across basic science, translational research, and clinical studies that are pushing the boundaries of the field. follow us on: Instagram - instagram.com/pathocast_review Tiktok - www.tiktok.com/@pathocast_rev

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Beyond the Years: How HIV and Obesity Rewire Ageing

Pathocast in Review

46 minutes 59 seconds

1 week ago

Beyond the Years: How HIV and Obesity Rewire Ageing

Welcome to Pathocast In Review – S1. Ep5 - On this fifth instalment we explore new evidence showing how HIV infection accelerates biological ageing, not just in years lived, but deep in the molecular architecture of antibodies revealing that changes in antibody glycosylation can predict ageing long before clinical signs appear, offering a molecular window into how chronic inflammation reshapes immune function. We then turn to obesity, a condition now understood to reprogram adipose tissue in lasting ways. Even after weight loss, fat tissue retains a form of metabolic memory, driving inflammation and accelerated cellular senescence. But here’s the hopeful part, this ageing process can be partially reversed by weight loss.Papers in Review:

1. Immunoglobulin G N-glycan markers of accelerated biological aging during chronic HIV infection. (DOI: 10.1038/s41467-024-47279-4).

2. Selective remodelling of the adipose niche in obesity and weight loss. (DOI: 10.1038/s41586-025-09233-2).

Moderator: Adijat Jimoh (@deejah_deej)

Panelists: Wealth Okete (@de_dew001) and Sonwabile Dzanibe (@⁠⁠⁠⁠⁠⁠⁠⁠sonwa_dzanibe⁠⁠)

Production: Zd Creations

Creator: Immun-Vir JC

Music: iLethu (@Mphephethwa_sa)