In this World Shared Practice Forum podcast, Dr. Robinder Khemani, co-author of the PALICC-2 guidelines, discusses the real-world application of pediatric ARDS management strategies. Through a case-based conversation, Dr. Khemani shares nuanced insights on intubation timing, ventilator settings, neuromuscular blockade, and rescue therapies, including ECMO. He also introduces the REDvent trial, a novel approach to lung and diaphragm protective ventilation. This content is ideal for clinicians, respiratory therapists, and healthcare educators seeking to deepen their understanding of evidence-informed, physiology-driven care in pediatric acute respiratory distress syndrome.
LEARNING OBJECTIVES
- Analyze the clinical decision-making process for intubation in pediatric ARDS
- Apply PEEP titration techniques to assess lung recruitability in patients with PARDS
- Evaluate the role of neuromuscular blockade in maintaining lung protective ventilation
- Identify appropriate advanced rescue therapies based on PARDS phenotypes
- Explore the principles and outcomes of the REDvent trial in ventilator management
AUTHORS
Robinder "Roby" Khemani, MD, MsCI
Professor of Pediatrics,
Vice Chair of Research
University of Southern California,
Department of Anesthesiology and Critical Care Medicine
Children's Hospital Los Angeles
Jeffrey Burns, MD, MPH
Emeritus Chief
Division of Critical Care Medicine
Department of Anesthesiology, Critical Care and Pain Medicine
Boston Children's Hospital
Professor of Anesthesia
Harvard Medical School
DATE
Initial publication date: October 28, 2025.
ARTICLE REFERENCED
Khemani RG, Bhalla A, Hotz JC, et al. Randomized Trial of Lung and Diaphragm Protective Ventilation in Children. NEJM Evid. 2025;4(6):EVIDoa2400360. doi:10.1056/EVIDoa2400360
TRANSCRIPT
https://cdn.bfldr.com/D6LGWP8S/at/47wbxnvxtcpvv54p48gc2v/202510_WSP_Khemani_Transcript.pdf
Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu
CITATION
Khemani RG, Burns JP. Practical Strategies for Management of Patients with Pediatric ARDS. 10/2025. OPENPediatrics. Online Podcast. https://soundcloud.com/openpediatrics/practical-strategies-for-management-of-patients-with-pediatric-ards-by-r-khemani-openpediatrics.
All content for OPENPediatrics is the property of OPENPediatrics and is served directly from their servers
with no modification, redirects, or rehosting. The podcast is not affiliated with or endorsed by Podjoint in any way.
In this World Shared Practice Forum podcast, Dr. Robinder Khemani, co-author of the PALICC-2 guidelines, discusses the real-world application of pediatric ARDS management strategies. Through a case-based conversation, Dr. Khemani shares nuanced insights on intubation timing, ventilator settings, neuromuscular blockade, and rescue therapies, including ECMO. He also introduces the REDvent trial, a novel approach to lung and diaphragm protective ventilation. This content is ideal for clinicians, respiratory therapists, and healthcare educators seeking to deepen their understanding of evidence-informed, physiology-driven care in pediatric acute respiratory distress syndrome.
LEARNING OBJECTIVES
- Analyze the clinical decision-making process for intubation in pediatric ARDS
- Apply PEEP titration techniques to assess lung recruitability in patients with PARDS
- Evaluate the role of neuromuscular blockade in maintaining lung protective ventilation
- Identify appropriate advanced rescue therapies based on PARDS phenotypes
- Explore the principles and outcomes of the REDvent trial in ventilator management
AUTHORS
Robinder "Roby" Khemani, MD, MsCI
Professor of Pediatrics,
Vice Chair of Research
University of Southern California,
Department of Anesthesiology and Critical Care Medicine
Children's Hospital Los Angeles
Jeffrey Burns, MD, MPH
Emeritus Chief
Division of Critical Care Medicine
Department of Anesthesiology, Critical Care and Pain Medicine
Boston Children's Hospital
Professor of Anesthesia
Harvard Medical School
DATE
Initial publication date: October 28, 2025.
ARTICLE REFERENCED
Khemani RG, Bhalla A, Hotz JC, et al. Randomized Trial of Lung and Diaphragm Protective Ventilation in Children. NEJM Evid. 2025;4(6):EVIDoa2400360. doi:10.1056/EVIDoa2400360
TRANSCRIPT
https://cdn.bfldr.com/D6LGWP8S/at/47wbxnvxtcpvv54p48gc2v/202510_WSP_Khemani_Transcript.pdf
Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu
CITATION
Khemani RG, Burns JP. Practical Strategies for Management of Patients with Pediatric ARDS. 10/2025. OPENPediatrics. Online Podcast. https://soundcloud.com/openpediatrics/practical-strategies-for-management-of-patients-with-pediatric-ards-by-r-khemani-openpediatrics.
Technology & Innovation in Pediatric ICUs: A Progressive Look at North America
OPENPediatrics
31 minutes 43 seconds
6 months ago
Technology & Innovation in Pediatric ICUs: A Progressive Look at North America
The World Federation of Pediatric Intensive & Critical Care Societies (WFPICCS), in collaboration with OPENPediatrics, recognizes World PICU Awareness Week 2025. This initiative aims to raise global awareness about the importance of PICUs and critical care wards worldwide, emphasizing how healthcare professionals in these units, regardless of resource setting, are driving change.
From predictive analytics to AI-driven teamwork, this episode explores how pediatric intensive care units across North America are blending technology and human insight to transform care. Hear experts from leading children’s hospitals in the U.S. discuss how innovation, frontline collaboration, and a focus on people, not just machines, are shaping the future of critical care for children.
HOST
Maya Dewan, MD, MPH
Division Director, Division of Critical Care
Attending Physician, Pediatric Intensive Care Unit & Associate Professor
UC Department of Pediatrics
Cincinnati Children’s Hospital
United States of America
GUESTS
Matthew Zackoff MD, Med
Director, Critical Care Fellowship Program
Co-Lead Digital Simulation, Center for Simulation and Research
Attending Physician, Pediatric Intensive Care Unit
Assistant Professor, UC Department of Pediatrics
Cincinnati Children’s Hospital
United States of America
Sanjiv Mehta, MD, MBE
Sanjiv D Mehta, MD, MBE, MSCE
Assistant Professor of Anesthesiology and Critical Care Medicine, University of Pennsylvania School of Medicine
Attending Physician, Division of Pediatric Critical Care Medicine, Children's Hospital of Philadelphia
Associate Medical Director for Analytics - ICU
United States of America
Jean Anne Cieplinski-Robertson, MSN, RN
Senior Director of Nursing, Critical Care
Children's Hospital of Philadelphia
United States of America
DATE
Initial publication date: May 8, 2025.
TRANSCRIPTS
English - https://cdn.bfldr.com/D6LGWP8S/at/b73v7gmf79nzjt9bt3vg3w/WPAW-25_North_America_Final_English.pdf
Spanish - https://cdn.bfldr.com/D6LGWP8S/at/2xjfmjbwfcw739f6f68tj4q/WPAW-25_North_America_Final_Spanish.pdf
French - https://cdn.bfldr.com/D6LGWP8S/at/9b4xsp88j7m3t438rpxrc62t/WPAW-25_North_America_Final_French.pdf
Portuguese - https://cdn.bfldr.com/D6LGWP8S/at/5bqn4q6fnw8b5gnr6swvvbx/WPAW-25_North_America_Final_Portuguese.pdf
Italian - https://cdn.bfldr.com/D6LGWP8S/at/3n2xjk7tvrqgmtwwhx3mb8nb/WPAW-25_North_America_Final_Italian.pdf
German - https://cdn.bfldr.com/D6LGWP8S/at/2q58jgjq7p99nxsgmbqp887/WPAW-25_North_America_Final_German.pdf
Arabic - https://cdn.bfldr.com/D6LGWP8S/at/ntsn8qpntsfkm65krzs6hqc/WPAW-25_North_America_Final_Arabic.pdf
Please visit: www.openpediatrics.org
OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access, thus at no expense to the user.
For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu
OPENPediatrics
In this World Shared Practice Forum podcast, Dr. Robinder Khemani, co-author of the PALICC-2 guidelines, discusses the real-world application of pediatric ARDS management strategies. Through a case-based conversation, Dr. Khemani shares nuanced insights on intubation timing, ventilator settings, neuromuscular blockade, and rescue therapies, including ECMO. He also introduces the REDvent trial, a novel approach to lung and diaphragm protective ventilation. This content is ideal for clinicians, respiratory therapists, and healthcare educators seeking to deepen their understanding of evidence-informed, physiology-driven care in pediatric acute respiratory distress syndrome.
LEARNING OBJECTIVES
- Analyze the clinical decision-making process for intubation in pediatric ARDS
- Apply PEEP titration techniques to assess lung recruitability in patients with PARDS
- Evaluate the role of neuromuscular blockade in maintaining lung protective ventilation
- Identify appropriate advanced rescue therapies based on PARDS phenotypes
- Explore the principles and outcomes of the REDvent trial in ventilator management
AUTHORS
Robinder "Roby" Khemani, MD, MsCI
Professor of Pediatrics,
Vice Chair of Research
University of Southern California,
Department of Anesthesiology and Critical Care Medicine
Children's Hospital Los Angeles
Jeffrey Burns, MD, MPH
Emeritus Chief
Division of Critical Care Medicine
Department of Anesthesiology, Critical Care and Pain Medicine
Boston Children's Hospital
Professor of Anesthesia
Harvard Medical School
DATE
Initial publication date: October 28, 2025.
ARTICLE REFERENCED
Khemani RG, Bhalla A, Hotz JC, et al. Randomized Trial of Lung and Diaphragm Protective Ventilation in Children. NEJM Evid. 2025;4(6):EVIDoa2400360. doi:10.1056/EVIDoa2400360
TRANSCRIPT
https://cdn.bfldr.com/D6LGWP8S/at/47wbxnvxtcpvv54p48gc2v/202510_WSP_Khemani_Transcript.pdf
Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu
CITATION
Khemani RG, Burns JP. Practical Strategies for Management of Patients with Pediatric ARDS. 10/2025. OPENPediatrics. Online Podcast. https://soundcloud.com/openpediatrics/practical-strategies-for-management-of-patients-with-pediatric-ards-by-r-khemani-openpediatrics.
