Welcome to the Oncology Brothers podcast! In this Challenging Cases episode, we take a deep dive into thrombocytopenia management—a common yet often perplexing topic in everyday hematology and oncology practice. We are joined by Dr. Ronak Mistry, hematologist at the University of Pennsylvania and co‑host of Fellows on Call, to walk through real‑world cases spanning ITP, anticoagulation with low platelets, and HIT. We covered essential topics such as:• Workup of thrombocytopenia and confirming the diagnosis of ITP• First‑ and second‑line ITP therapy—steroids, IVIG, TPO receptor agonists, and splenectomy• ⁠Managing anticoagulation in thrombocytopenic patients with cirrhosis and DVT• ⁠Step‑by‑step approach to suspected HIT in the inpatient setting• Rapid‑fire tips—transfusion thresholds, chemo‑related thrombocytopenia, and medication culprits Whether you’re a hematologist, oncologist, or internal medicine resident, this episode is packed with case‑based teaching points, practical pearls, and the latest guidance from ASH and NCCN for non‑malignant hematology. Follow us on social media:•⁠  ⁠X/Twitter: https://twitter.com/oncbrothers•⁠  ⁠Instagram: https://www.instagram.com/oncbrothers•⁠  Website: https://oncbrothers.com/ Don’t forget to like, subscribe, and tune in for more challenging case discussions, treatment strategies, and expert insights from the world of hematology and oncology! #Thrombocytopenia #HematologyPodcast #ITP #HIT #OncologyBrothers