Professor Gerben Keijzers discuss critical themes in clinical practice, focusing on clinical reasoning, evidence-based practice, and traditional methods. They highlight the importance of understanding likelihood ratios, cognitive biases, and problem representation in diagnosis, alongside the effective use of clinical decision tools. The conversation underscores the value of incorporating patient perspectives into decision-making and balancing evidence with experience. Gerbern shares practical strategies to minimise biases and encourages clinicians to refine their decision-making styles while staying adaptable to patient needs. He emphasises the detective-like role of clinicians, combining reasoning with patient-personalised care. Website links discussed in show https://first10em.com/clinical-decision-rules/ https://onlinelibrary.wiley.com/doi/abs/10.1111/1742-6723.13126 Chapters 00:00 Introduction and Acknowledgments 04:15 Clinical Reasoning in Practice 11:07 Evidence-Based Practice vs Traditional Medicine 17:51 Understanding Likelihood Ratios 26:14 Using Clinical Decision Tools Effectively 30:12 Understanding Clinical Decision Rules 31:01 Clinical Reasoning vs. Critical Thinking 34:55 The Importance of Problem Representation 39:50 Navigating Cognitive Biases in Clinical Practice 45:15 Strategies to Minimize Bias in Decision Making 53:18 Evidence-Based Medicine and Patient-Centered Care