In this episode, we discuss how overeating can lead to inflammation and neuron dysfunction in specific parts of the brain that control appetite and energy regulation. We review the neuroscience of appetite regulation, energy expenditure, and body fat regulation. Topics include hypothalamic dysfunction of body fat regulation, leptin resistance, neuro-inflammation, and physical changes in the hypothalamus involving microglia (the immune cells of the brain). We also review what is known about avoiding and reversing these changes.

Chapters:

00:00:00 - Introduction
00:00:37 - Brain Changes in Obesity
00:01:20 - Leptin Deficiency & Obesity
00:03:25 - Leptin Replacement
00:04:43 - Hypothalamic Obesity
00:05:42 - What is the Hypothalamus?
00:06:51 - Food Intake, Appetite, & VMH
00:08:50 - Ob Gene
00:09:34 - The Satiety Factor
00:11:11 - Leptin Paradox
00:11:51 - Leptin Resistance
00:13:41 - Leptin Physiology
00:15:03 - Leptin Resistance
00:18:11 - Effects of Leptin Resistance
00:18:29 - Improving Leptin Resistance
00:20:24 - Hypothalamic Inflammation
00:24:08 - Triggers of Hypothalamic Inflammation
00:25:45 - Fatty Acids & Hypothalamic Inflammation
00:26:24 - Advanced Glycation End Products (AGEs)
00:27:05 - Current Knowledge on Hypothalamic Inflammation
00:28:17 - Summary
00:30:16 - Outro

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References & Show Notes:

http://www.nicksterling.com/