How Bacteria in Your Gut Control Metabolic Health - Akkermansia & GLP-1

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Nick Sterling, MD, PhD

20 episodes

1 week ago

Physician focused on the science of preventative health, aging, and athletic performance.

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Physician focused on the science of preventative health, aging, and athletic performance.

Health & Fitness

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How Bacteria in Your Gut Control Metabolic Health - Akkermansia & GLP-1 - Colleen Cutcliffe, PhD

Nick Sterling, MD, PhD

48 minutes 2 seconds

4 months ago

How Bacteria in Your Gut Control Metabolic Health - Akkermansia & GLP-1 - Colleen Cutcliffe, PhD

Scientific knowledge of the gut microbiome has increased exponentially over the last decade. Recently, several studies have suggested that specific strains of bacteria, including Akkermansia muciniphila, are key to supporting the environmental conditions required for other related bacterial strains that facilitate healthy metabolic health. In this video, Colleen Cutcliffe, PhD, co-founder and CEO of Pendulum discusses groundbreaking research around Akkermansia mucinophila, the role of short-chain fatty acids (SCFAs) in stimulating GLP-1 pathways, implications for diabetes management, and how gut bacteria influence inflammation, gut integrity, and overall metabolic health. They also explore how diet, antibiotics, and stress impact the microbiome, potential roles of probiotics in inflammatory bowel disease (IBD), pediatric gut health, and exciting emerging research on the gut-brain axis and neurological conditions like Parkinson's disease. Colleen highlights Pendulum's rigorous scientific approach, including clinical trials and innovative manufacturing practices that ensure product viability and effectiveness.

Promotional code STERLING20 can be applied for 20% off of first membership purchases (https://pendulumlife.com). Please note that Dr. Sterling has no financial affiliation with Pendulum. This code is provided only as a discount to listeners and does not constitute a clinical recommendation or medical advice.

Chapters:

- 00:00 Intro: Gut Microbiome Essentials

- 02:03 Pendulum's Biotech Innovation

- 06:15 GLP-1 & Metabolic Health

- 09:59 Probiotic Industry Insights

- 17:17 Importance of Akkermansia

- 24:17 Clinical Results for Diabetes

- 29:28 Manufacturing Challenges

- 39:13 Diet's Impact on Microbiome

- 43:35 Gut-Brain Connection

- 46:50 Next Steps & Resources

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