On February 27, 2025 we were joined by Xue Han about using genetically expressed fluorescent voltage sensors to measure transmembrane voltage simultaneously in multiple neurons in the brain of awake behaving animals over days or weeks. She explained how the genetic sequences for the voltage sensor molecules are found and perfected, how they are delivered to the neurons of interest, the challenges of measuring voltage by changes in fluorescence, and the kinds of questions whose solutions are waiting for this technology.

Guest:

Xue Han, Professor, Department of Biomedical Engineering, Boston University

Host:

Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA

Thanks to Jim Tepper for original music