In episode seven of our Neuroscience Research series, Filippo Dall'Armellina and Dr. Michael Cearns speak with Dr. Nicoletta Landsberger from the University of Milan. Her research focuses on Rett syndrome: a rare, severe X-linked neurodevelopmental disorder and a leading cause of intellectual disability in females. They discuss how the disease progresses in Mecp2-deficient mice, the therapeutic potential of neural precursor cell transplants, and a promising non-invasive treatment strategy: intranasal delivery of nerve growth factor.
Research Highlights from the Episode:
- Paper 1: Carli et al. A comprehensive longitudinal study of magnetic resonance imaging identifies novel features of the Mecp2-deficient mouse brain. Neurobiology of Disease, 2023. PMID: 36931532.
- Paper 2: Frasca et al. Neural precursor cells rescue symptoms of Rett syndrome by activation of the Interferon γ pathway. EMBO, 2024. PMID: 39496971.
- Paper 3: Pozzer et al. Clinical-grade intranasal NGF fuels neurological and metabolic functions of Mecp2-deficient mice. Brain, 2025. PMID: 39300821.
🧠#NeuroscienceResearch
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In episode seven of our Neuroscience Research series, Filippo Dall'Armellina and Dr. Michael Cearns speak with Dr. Nicoletta Landsberger from the University of Milan. Her research focuses on Rett syndrome: a rare, severe X-linked neurodevelopmental disorder and a leading cause of intellectual disability in females. They discuss how the disease progresses in Mecp2-deficient mice, the therapeutic potential of neural precursor cell transplants, and a promising non-invasive treatment strategy: intranasal delivery of nerve growth factor.
Research Highlights from the Episode:
- Paper 1: Carli et al. A comprehensive longitudinal study of magnetic resonance imaging identifies novel features of the Mecp2-deficient mouse brain. Neurobiology of Disease, 2023. PMID: 36931532.
- Paper 2: Frasca et al. Neural precursor cells rescue symptoms of Rett syndrome by activation of the Interferon γ pathway. EMBO, 2024. PMID: 39496971.
- Paper 3: Pozzer et al. Clinical-grade intranasal NGF fuels neurological and metabolic functions of Mecp2-deficient mice. Brain, 2025. PMID: 39300821.
🧠#NeuroscienceResearch
X/Twitter: @NPodcases
Visit the Neuro Podcases website: neuropodcases.co.uk
Surgical trials and meningiomas with Prof. Michael Jenkinson
Neuro Podcases
28 minutes 53 seconds
1 year ago
Surgical trials and meningiomas with Prof. Michael Jenkinson
In this episode of our Neuroscience Research series, hosts Filippo Dall'Armellina and Michael Cearns engage in a compelling discussion with Professor Michael Jenkinson, Chair of Surgical Trials at the University of Liverpool. They explore his pioneering work in surgical trials to understand meningiomas, a type of brain tumours.
Research Highlights from the Episode:
- IMPACT study publication: Islim AI, et al. External validation and recalibration of an incidental meningioma prognostic model - IMPACT. BMJ Open. 2022.
- STOP'EM trial. Learn more about it at https://www.fundingawards.nihr.ac.uk/award/NIHR129748.
🧠#NeuroscienceResearch
X/twitter @NPodcases
Neuro Podcases Website at neuropodcases.co.uk
Neuro Podcases
In episode seven of our Neuroscience Research series, Filippo Dall'Armellina and Dr. Michael Cearns speak with Dr. Nicoletta Landsberger from the University of Milan. Her research focuses on Rett syndrome: a rare, severe X-linked neurodevelopmental disorder and a leading cause of intellectual disability in females. They discuss how the disease progresses in Mecp2-deficient mice, the therapeutic potential of neural precursor cell transplants, and a promising non-invasive treatment strategy: intranasal delivery of nerve growth factor.
Research Highlights from the Episode:
- Paper 1: Carli et al. A comprehensive longitudinal study of magnetic resonance imaging identifies novel features of the Mecp2-deficient mouse brain. Neurobiology of Disease, 2023. PMID: 36931532.
- Paper 2: Frasca et al. Neural precursor cells rescue symptoms of Rett syndrome by activation of the Interferon γ pathway. EMBO, 2024. PMID: 39496971.
- Paper 3: Pozzer et al. Clinical-grade intranasal NGF fuels neurological and metabolic functions of Mecp2-deficient mice. Brain, 2025. PMID: 39300821.
🧠#NeuroscienceResearch
X/Twitter: @NPodcases
Visit the Neuro Podcases website: neuropodcases.co.uk
