In episode seven of our Neuroscience Research series, Filippo Dall'Armellina and Dr. Michael Cearns speak with Dr. Nicoletta Landsberger from the University of Milan. Her research focuses on Rett syndrome: a rare, severe X-linked neurodevelopmental disorder and a leading cause of intellectual disability in females. They discuss how the disease progresses in Mecp2-deficient mice, the therapeutic potential of neural precursor cell transplants, and a promising non-invasive treatment strategy: intranasal delivery of nerve growth factor.
Research Highlights from the Episode:
- Paper 1: Carli et al. A comprehensive longitudinal study of magnetic resonance imaging identifies novel features of the Mecp2-deficient mouse brain. Neurobiology of Disease, 2023. PMID: 36931532.
- Paper 2: Frasca et al. Neural precursor cells rescue symptoms of Rett syndrome by activation of the Interferon γ pathway. EMBO, 2024. PMID: 39496971.
- Paper 3: Pozzer et al. Clinical-grade intranasal NGF fuels neurological and metabolic functions of Mecp2-deficient mice. Brain, 2025. PMID: 39300821.
🧠#NeuroscienceResearch
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In episode seven of our Neuroscience Research series, Filippo Dall'Armellina and Dr. Michael Cearns speak with Dr. Nicoletta Landsberger from the University of Milan. Her research focuses on Rett syndrome: a rare, severe X-linked neurodevelopmental disorder and a leading cause of intellectual disability in females. They discuss how the disease progresses in Mecp2-deficient mice, the therapeutic potential of neural precursor cell transplants, and a promising non-invasive treatment strategy: intranasal delivery of nerve growth factor.
Research Highlights from the Episode:
- Paper 1: Carli et al. A comprehensive longitudinal study of magnetic resonance imaging identifies novel features of the Mecp2-deficient mouse brain. Neurobiology of Disease, 2023. PMID: 36931532.
- Paper 2: Frasca et al. Neural precursor cells rescue symptoms of Rett syndrome by activation of the Interferon γ pathway. EMBO, 2024. PMID: 39496971.
- Paper 3: Pozzer et al. Clinical-grade intranasal NGF fuels neurological and metabolic functions of Mecp2-deficient mice. Brain, 2025. PMID: 39300821.
🧠#NeuroscienceResearch
X/Twitter: @NPodcases
Visit the Neuro Podcases website: neuropodcases.co.uk
In this inaugural episode of our Neuroscience Research series, hosts Filippo Dall'Armellina and Michael Cearns are joined by Professor Tony Marson who leads the Liverpool Epilepsy Research Group and is a honorary consultant neurologist at The Walton Centre NHS Foundation Trust. Together, they explore Professor Marson's career in epilepsy research, answering practical questions in the field.
Research Highlights from the Episode:
- Paper 1: Terman SW, et al. Variation in seizure risk increases from antiseizure medication withdrawal among patients with well-controlled epilepsy: A pooled analysis. Epilepsia Open. 2024.
- Paper 2: Mayer J, et al. Epilepsy and the risk of adverse cardiovascular events: A nationwide cohort study. Eur J Neurol. 2024.
🧠#NeuroscienceResearch
X/twitter @NPodcases
Neuro Podcases Website at neuropodcases.co.uk
Neuro Podcases
In episode seven of our Neuroscience Research series, Filippo Dall'Armellina and Dr. Michael Cearns speak with Dr. Nicoletta Landsberger from the University of Milan. Her research focuses on Rett syndrome: a rare, severe X-linked neurodevelopmental disorder and a leading cause of intellectual disability in females. They discuss how the disease progresses in Mecp2-deficient mice, the therapeutic potential of neural precursor cell transplants, and a promising non-invasive treatment strategy: intranasal delivery of nerve growth factor.
Research Highlights from the Episode:
- Paper 1: Carli et al. A comprehensive longitudinal study of magnetic resonance imaging identifies novel features of the Mecp2-deficient mouse brain. Neurobiology of Disease, 2023. PMID: 36931532.
- Paper 2: Frasca et al. Neural precursor cells rescue symptoms of Rett syndrome by activation of the Interferon γ pathway. EMBO, 2024. PMID: 39496971.
- Paper 3: Pozzer et al. Clinical-grade intranasal NGF fuels neurological and metabolic functions of Mecp2-deficient mice. Brain, 2025. PMID: 39300821.
🧠#NeuroscienceResearch
X/Twitter: @NPodcases
Visit the Neuro Podcases website: neuropodcases.co.uk
