Dr. Andy Beam has trained models, mentored scientists, and used data to quantify the value of treatments. In this episode of NEJM AI Grand Rounds, Raj Manrai turns the table on his co-host, reflecting on how Andy’s childhood misdiagnosis, and the failure of human recall, revealed the diagnostic promise of machine learning. As a Harvard professor, he mentored hybrid thinkers and built tools to evaluate safety, not just performance. Now CTO of Lila Sciences, he’s building an experimental AI system to generate its own hypotheses and test them in the real world. This conversation is a front-row seat to the next evolution of science. Transcript.