The HIV epidemic endures within the global health sphere. As of 2022, approximately 39 million people live with HIV/AIDS worldwide; eliminating the viral threat remains challenging. Scientific and clinical efforts to eradicate HIV/AIDS have been ongoing for decades, yet we are still left without a vaccine or cure for the virus. But there is still much hope and promise in modern research. Major strides have been made in developing therapies for people living with HIV and preventing new infections within communities. The light at the end of the tunnel grows brighter as research and development ramp up. In this week’s episode, we invited the Chief of Pitt’s Division of Infectious Diseases, John Mellors, MD, as well as Associate Professor of Medicine, Bernard “Beej” Macatangay, MD, to discuss the current state of HIV research. Please join us as we consider the unusual characteristics of HIV and why they create difficulties in vaccine development. We also discuss approaches to treatment as prevention, the roles vaccines play in therapeutic HIV treatments, and developments in reaching undetectable status. Is there hope for an end to the epidemic?