Can adenosine and a ketogenic diet help treat addiction? New research explores the powerful role of adenosine, dopamine, and metabolic health in addiction, and how dietary strategies could support recovery.
In this interview, Dr. Bret Scher speaks with Dr. Susan Masino, a neuroscience and psychology professor at Trinity College, about her groundbreaking work on adenosine and its potential to regulate addiction through metabolic pathways. They dive into:
Dr. Masino also shares insights on how habits, stress, inflammation, and neuroplasticity all intersect with metabolic health—and what that means for mental health and addiction treatment going forward.
Expert Featured:
Dr. Susan Masino
Resources Mentioned:
Ketogenic diet, adenosine, and dopamine in addiction and psychiatry
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1492306/full
Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.
Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/
About us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
Have you ever thought about stopping psychiatric medications? Maybe you have tried it.
If so, you’re not alone. Many individual across the world have considered or tried stopping their psychiatric medications and success is variable.
The withdrawal from psychiatric medication tapering can be incredibly complex, and doing it safely requires both medical and psychological support.
But, as Dr. Anders Sørensen highlights in this interview, the guidelines around medication tapering and withdrawal miss a lot of important nuances that can prevent people from being successful.
In this interview, psychologist and PhD researcher Dr. Anders Sørensen shares his decade-long experience helping people taper off psychiatric medications. He covers the biological and emotional aspects of withdrawal, the science behind tapering strategies like hyperbolic tapering, and why psychotherapy plays a vital role during and after the process. You'll also learn how short-term clinical studies shaped medical guidelines and why those guidelines may not reflect the lived experience of long-term patients.
In this video, you'll also learn:
Watch for Dr. Sørensen’s forthcoming book “Crossing Zero: The Art and Science of Coming and Staying Off Psychiatric Drugs” coming in summer 2025.
Expert Featured:
Resources Mentioned:
Clinical practice guideline recommendations on tapering and discontinuing antidepressants for depression: a systematic review
Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.
Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/
About us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
Is it really treatment-resistant depression or are we using the wrong treatments?
In this episode, Dr. Bret Scher is joined by psychiatrist Dr. Georgia Ede to examine a new large, population-based analysis on the use of antipsychotics versus third-line antidepressants in people diagnosed with treatment-resistant depression, and what effect that has on suicide risk.
They discuss:
This conversation explores why conventional approaches may fall short, and how metabolic psychiatry offers promising, low-risk alternatives.
📌 Please note: This episode discusses suicide and may be triggering for some viewers.
Expert Featured:
Dr. Georgia Ede, MD
Resources Mentioned
Antipsychotic therapy and suicide risk in patients with treatment-resistant depression: target trial emulation framework study
CMEs Mentioned:
Managing Major Mental Illness with Dietary Change: The New Science of Hope
Brain Energy: The Metabolic Theory of Mental Illness
Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.
Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/
About us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
Can exogenous ketones help treat mental illness? In this interview, psychiatry resident and researcher in the Netherlands Dr. Karin Huizer shares groundbreaking insights into her pilot study using ketone esters for mental health. The hope is that this early research will inform us to whether or not supplemental ketones are a viable option for mental health, which could be especially useful for patients who struggle to follow a full ketogenic diet.
Dr. Huizer brings a unique perspective as both a scientist and someone living with bipolar disorder. She discusses:
This conversation is full of insight, compassion, and hope for more effective, science-backed treatments in mental health.
Watch now to learn how metabolic interventions are evolving and what that could mean for patients worldwide.
Expert Featured:
Resources Mentioned:
Managing Major Mental Illness with Dietary Change: The New Science of Hope
Brain Energy: The Metabolic Theory of Mental Illness
Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.
Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/
About us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
Youth mental illness is on the rise, and treatment options are often limited, especially for kids with bipolar disorder. This Mental Health Awareness Month, we’re highlighting a groundbreaking new real-world data collection funded by the Baszucki Group exploring ketogenic therapy as a promising intervention for children and adolescents living with bipolar disorder.
In this interview, Elizabeth Errico, founder of the Children's Mental Health Resource Center (CMHRC), shares how her organization is implementing ketogenic therapy in a real-world setting for kids aged 6 to 17. The year-long study is part of a larger initiative supported by the Baszucki Group to expand mental health care options through metabolic approaches.
Families in the program receive education, hands-on support, and guidance to help implement this dietary therapy at home—often with life-changing results.
In this video, you’ll learn:
This is about more than data—it's about hope, empowerment, and building a better path forward for families navigating serious mental illness.
Expert Featured:
Other Resources Mentioned:
Managing Major Mental Illness with Dietary Change: The New Science of Hope
Brain Energy: The Metabolic Theory of Mental Illness
Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.
Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/
About us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
Can ketogenic therapy help reduce or even resolve symptoms of obsessive compulsive disorder (OCD)? Dr. Chris Palmer and research assistant Aaron MacDonald join Metabolic Mind to discuss one of the first published case series exploring metabolic and ketogenic interventions for OCD. In this video, you’ll learn: - Why OCD deserves more attention as a serious, life-limiting condition - How three individuals saw dramatic symptom relief using a therapeutic ketogenic diet - What role ketosis may play in symptom reduction and why results varied from two weeks to a full year - The potential mechanisms behind metabolic therapies and brain energy metabolism - Why more research, including randomized controlled trials, is urgently needed This conversation is especially valuable for clinicians, patients, and families seeking new approaches for treatment-resistant OCD. It also touches on broader implications of metabolic health across a range of mental illnesses, including bipolar disorder and schizophrenia, and the importance of supervised, individualized treatment plans. Hear how both guests bring personal experience with OCD into their research, and why they’re hopeful this work will pave the way for better, much-needed options in mental health care. Experts Featured:- Dr. Chris Palmer, MD Website - https://chrispalmermd.com - Book: https://brainenergy.com - Aaron John MacDonald, research assistant in the Metabolic and Mental Health Program at McLean Hospital Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org
About us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
